186371-01-7Relevant academic research and scientific papers
3D-QSAR study of adamantyl N-benzylbenzamides as melanogenesis inhibitors
Hong, Yong Deog,Baek, Heung Soo,Cho, Haelim,Ahn, Soo Mi,Rho, Ho Sik,Park, Young-Ho,Joo, Yung Hyup,Shin, Song Seok
, p. 667 - 673 (2014)
Three-dimensional quantitative structure-activity relationship (3D-QSAR) modeling, comparative molecular field analysis (CoMFA), and comparative molecular similarity indices analysis (CoMSIA) of polyhydroxylated N-benzylbenzamide derivatives containing an
New bitter-masking compounds: Hydroxylated benzoic acid amides of aromatic amines as structural analogues of homoeriodictyol
Ley, Jakob P.,Blings, Maria,Paetz, Susanne,Krammer, Gerhard E.,Bertram, Heinz-Jurgen
, p. 8574 - 8579 (2006)
Starting from the known bitter-masking flavanones eriodictyol and homoeriodictyol from herba santa some structurally related hydroxybenzoic acid amides of benzylamines were synthesized and evaluated as masking agents toward bitterness of caffeine by senso
Adamantyl N-benzylbenzamide: New series of depigmentation agents with tyrosinase inhibitory activity
Baek, Heung Soo,Hong, Yong Deog,Lee, Chang Seok,Rho, Ho Sik,Shin, Song Seok,Park, Young-Ho,Joo, Yung Hyup
experimental part, p. 2110 - 2113 (2012/04/18)
A new series of polyhydroxylated N-benzylbenzamide derivatives containing an adamantyl moiety has been synthesized, and the depigmenting and tyrosinase inhibitory activities of the molecules were evaluated. The lipophilic character of the adamantyl moiety
Syntheses and biological activities of joro spider toxin analogs to spidamine and joramine
Chiba, Tadashige,Akizawa, Toshifumi,Matsukawa, Motomi,Kawai, Nobufumi,Kono, Yoshiaki,Yoshioka, Masanori
, p. 93 - 100 (2007/10/03)
In order to study the structure-activity relationships of spidamine and joramine found in the venom of Joro spider, Nephila clavata, we attempted to synthesize various analogs. Six analogs were convergently synthesized according to our previous method for the synthesis of spidamine, N-(3- aminopropyl-β-alanyl)-N'-(2,4-dihydroxyphenylacetyl-L-asparaginyl)-1,5- pentanediamine and joramine, N-(3-aminopropyl-β-alanyl)-N'-(4- hydroxyphenylacetyl-L-asparaginyl)-1,5-pentanediamine. The biological activities of the analogs and four intermediates were compared with those of synthetic spidamine and joramine in three bioassay systems, lobster neuromuscular synapse, cockroaches and mosquito larvae. The glutamate receptors in these systems were inhibited by some analogs, and the D- asparagine- or indoleacetyl-containing analogs were found to be strong inhibitors. These compounds have potential application as insecticides.
