186395-08-4

Upstream product

• 67-56-1 methanol 
• 1878-92-8 2-(2-iodophenoxy)acetic acid 
• 533-58-4 2-Iodophenol 
• 96-32-2 bromoacetic acid methyl ester 
• 96-34-4 methyl chloroacetate 

Downstream Products

• 202126-65-6 Methyl (4'-benzyloxybiphenyl-2-yloxy)acetate 
• 533-58-4 2-Iodophenol 
• 938443-85-7 methyl 2-(2-benzoylphenoxy)acetate 
• 938443-86-8 methyl 3-phenylbenzofuran-2-carboxylate 
• 38930-22-2 methyl 2-(2,6-dimethylphenoxy)acetate 
• 202126-68-9 Methyl [4'-(2,4-dinitrophenoxy)biphenyl-2-yloxy]acetate 
• 202126-69-0 [4'-(2,4-Dinitrophenoxy)biphenyl-2-yloxy]acetic acid 

Relevant academic research and scientific papers

Pd-Catalyzed ipso, meta-Dimethylation of ortho-Substituted Iodoarenes via a Base-Controlled C-H Activation Cascade with Dimethyl Carbonate as the Methyl Source

A methyl group can have a profound impact on the pharmacological properties of organic molecules. Hence, developing methylation methods and methylating reagents is essential in medicinal chemistry. We report a palladium-catalyzed dimethylation reaction of ortho-substituted iodoarenes using dimethyl carbonate as a methyl source. In the presence of K2CO3 as a base, iodoarenes are dimethylated at the ipso- and meta-positions of the iodo group, which represents a novel strategy for meta-C-H methylation. With KOAc as the base, subsequent oxidative C(sp3)-H/C(sp3)-H coupling occurs; in this case, the overall transformation achieves triple C-H activation to form three new C-C bonds. These reactions allow expedient access to 2,6-dimethylated phenols, 2,3-dihydrobenzofurans, and indanes, which are ubiquitous structural motifs and essential synthetic intermediates of biologically and pharmacologically active compounds.

Aniline derivatives, their manufacture and use as pharmaceuticals

This invention relates to compounds of the formula wherein X is N and Y is S or O; or X is S or O and Y is N; R1 is hydrogen or C1-7-alkyl; R2 and R3 independently from each other are selected from the group con

New carbon radical chemistry as a model for the biogenesis of the interiorin/kadsulignan type of dibenzocyclooctadiene lignan

Novel intramolecular radical spirocyclisation reactions in aromatic nuclei, 48→49, 40→22 and 34→32, are presented, which mimic a key step in the proposed biosynthesis of the interiorins 2a-d, the kadsulignans 3a,b and relatives.

Applicability of Hammett Equation to Kinetics of Acid-catalysed Esterification of ortho-Substituted Phenoxyacetic, Phenylmercaptoacetic and Phenylsulphonylacetic Acids by Methanol

Correlation analysis of the title rate data shows that the steric effects of ortho-substituents are absent at the reaction centre.