186413-79-6

Basic information

• Product Name: 3-AMINO-2-METHOXY-6-PICOLINE
• Synonyms: 3-AMINO-2-METHOXY-6-METHYLPYRIDING;3-Pyridinamine,2-methoxy-6-methyl-(9CI);3-AMINO-2-METHOXY-6-METHYLPYRIDINE;2-methoxy-6-methylpyridin-3-amine;6-methoxy-2-methylpyridin-3-amine;2-Methoxy-6-methyl-3-pyridinamine;5-AMINO-6-METHOXY-2-METHYLPYRIDINE;3-AMINO-2-METHOXY-6-PICOLINE
• CAS NO: 186413-79-6
• Molecular Formula: C₇H₁₀N₂O
• Molecular Weight: 138.17
• Product Categories: PYRIDINE;AMINEPRIMARY
• Mol File: 186413-79-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 246.688 °C at 760 mmHg
• Flash Point: 102.993 °C
• Appearance: Dark brown/Liquid
• Density: 1.103 g/cm³
• Vapor Pressure: 0.027mmHg at 25°C
• Refractive Index: 1.553
• PKA: 5.05±0.10(Predicted)
• CAS DataBase Reference: 3-AMINO-2-METHOXY-6-PICOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-2-METHOXY-6-PICOLINE(186413-79-6)
• EPA Substance Registry System: 3-AMINO-2-METHOXY-6-PICOLINE(186413-79-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 186413-79-6(Hazardous Substances Data)

Usage

Uses

3-Amino-2-methoxy-6-picoline is a useful reagent in the synthesis of aminopyridinecarboxylic acid and derivatives as precursors for streptonigrin analogs.

InChI:InChI=1/C7H10N2O/c1-5-3-4-6(8)7(9-5)10-2/h3-4H,8H2,1-2H3

Upstream product

• 68957-50-6 2-amino-5-bromo-6-methyl-3-nitropyridine 
• 19346-45-3 2-fluoro-3-nitro-6-methylpyridine 
• 112163-03-8 5-nitro-6-methoxy-2-methylpyridine 
• 186413-74-1 5-Bromo-6-methyl-3-nitro-1H-pyridin-2-one 
• 186413-75-2 3-bromo-6-chloro-2-methyl-5-nitropyridine 
• 186413-76-3 5-bromo-2-methoxy-6-methyl-3-nitropyridine 

Downstream Products

• 186414-01-7 Trifluoro-methanesulfonic acid 4-(2-diethylcarbamoyloxy-3,4-dimethoxy-phenyl)-3-(2,2-dimethyl-propionylamino)-6-methyl-pyridin-2-yl ester 
• 186413-98-9 N-(4-Iodo-6-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-2,2-dimethyl-propionamide 

Relevant articles and documents

COMBINATION OF AN AZETIDINE LPA1 RECEPTOR ANTAGONIST WITH PIRFENIDONE AND/OR NINTEDANIB FOR USE IN THE TREATMENT OF FIBROTIC DISEASES

The present invention concerns the compounds of formula (I) wherein R1, R2, R3, X, and Y are as described in the description, and their use as antagonists of the LPA1 receptor, in combination with one or more therapeutically active ingredients acting as anti-fibrotic agent(s); such as especially pirfenidone and/or nintedanib, in the prevention and/or treatment of fibrotic diseases. The invention further relates to pharmaceutical compositions comprising the compounds of formula (I) in combination with one or more therapeutically active ingredients acting as anti-fibrotic agent(s) such as pirfenidone or nintedanib.

Synthesis of new pyridine intermediates as precursors for the elaboration of streptonigrin analogues by the metalation-cross-coupling strategy

Starting from available 2-amino-6-chloro-3-nitropyridine, synthesis of 3-amino-6-pyridinecarboxylic acid derivatives precursor for pyridine ring C of streptonigrin analogues is described.