186429-07-2

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 186429-03-8 (S)-N-benzyl-3-(1-ethoxy)ethoxy-4-hydroxybutyramide 
• 263164-11-0 (S)-3-(1-ethoxy)ethoxy-γ-butyrolactone 

Downstream Products

• 186429-12-9 (S)-4-(1-ethoxy)ethoxy-2-oxopyrrolidine 
• 186429-04-9 (S)-N-benzyl-4-(1-ethoxy)ethoxy-2-oxopyrrolidine 

Relevant academic research and scientific papers

Efficient syntheses of (S)-4-hydroxy-2-pyrrolidinone derivatives

Efficient syntheses of (S)-4-hydroxy-2-pyrrolidinone ((5)-2) and (R)4- acetylthio-2-pyrrolidinone (S), which are key intermediates of oral carbapenem CS-834, were studied. The most efficient route to (S)-2 from (S)- 3-hydroxybutyrolactone (8) was accomplished in high yield via (S)-N-allyl-3- (1-ethoxy)ethoxy-4-hydroxybutyramide (14).