186489-72-5

Upstream product

• 101712-01-0 (R)-1-((R)-4-benzyl-2-oxooxazolidin-3-yl)-2-methylpentane-1,3-dione 
• 186489-71-4 (4R,2'R,4'S)-3-(2',4'-dimethyl-3'-oxo-5'-hydroxyheptanoyl)-4-benzyl-2-oxazolidinone 

Downstream Products

• 186489-73-6 (R)-4-Benzyl-3-[(2R,3S,4R,5R)-5-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-2,4-dimethyl-heptanoyl]-oxazolidin-2-one 
• 186489-76-9 1-{(Z)-(1S,2R)-1-[(1R,2R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-butyl]-2-methyl-3-trimethylsilanyloxy-pent-3-enyloxymethyl}-4-methoxy-benzene 
• 171005-61-1 (R)-4-Benzyl-3-((R)-2-{(4S,5R,6S)-6-[(1S,2S,3R,5R,6S,7R,8R)-8-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-6-(4-methoxy-benzyloxy)-1,3,5,7-tetramethyl-4-oxo-decyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-propionyl)-oxazolidin-2-one 
• 186489-75-8 (4R,5S,6R,7R)-7-(t-butyldimethylsilyloxy)-5-[(p-methoxybenzyl)oxy]-4,6-dimethylnonan-3-one 
• 623927-76-4 4-(R)-benzyl-3-[(2R,3S,4S,5R)-5-(tert-butyldimethylsilanyloxy)-3-propionyloxy-2,4-dimethylheptanoyl]-oxazolidin-2-one 

Relevant academic research and scientific papers

Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase

6-Deoxyerythronolide B synthase (DEBS) is a modular polyketide synthase (PKS) responsible for the biosynthesis of 6-dEB (1), the parent aglycone of the broad spectrum macrolide antibiotic erythromycin. Individual DEBS modules, which contain the catalytic

General strategies toward the syntheses of macrolide antibiotics. The total syntheses of 6-deoxyerythronolide B and oleandolide

The asymmetric syntheses of 6-deoxyerythronolide B (1) and oleandolide (2) have been achieved, each in 18 linear steps. These syntheses demonstrate the utility of chiral β-keto imide building block 3 as a versatile building block for the aldol-based assemblage of polypropionate-derived natural products.