186489-73-6

Upstream product

• 69739-34-0 t-butyldimethylsiyl triflate 
• 186489-72-5 (4R,2'R,3'S,4'S)-3-(2',4'-dimethyl-3',5'-dihydroxyheptanoyl)-4-benzyl-2-oxazolidinone 
• 145937-04-8 (2S,3R)-3-hydroxy-N-methoxy-N,2-dimethylpentanamide 
• 145937-05-9 (2S,3R)-3-(tert-butyldimethylsilyloxy)-N-methoxy-N,2-dimethylpentanamide 
• 124356-91-8 (4S,2'S,3'R)-3-(2'-methyl-3'-hydroxypentanoyl)-4-benzyl-2-oxazolidinone 
• 186489-71-4 (4R,2'R,4'S)-3-(2',4'-dimethyl-3'-oxo-5'-hydroxyheptanoyl)-4-benzyl-2-oxazolidinone 
• 101712-01-0 (R)-1-((R)-4-benzyl-2-oxooxazolidin-3-yl)-2-methylpentane-1,3-dione 
• 114181-55-4 (2S,3R)-3-(tert-butyldimethylsilyloxy)-2-methylpentanal 
• 101711-78-8 (3R)-3-propionyl-4-benzyloxazolidin-2-one 
• 220272-52-6 (S)-4-benzyl-3-((2S,3R)-3-((tert-butyldimethylsilyl)oxy)-2-methylpentanoyl)oxazolidin-2-one 
• 78433-59-7 (2R,3R)-3-<(tert-butyldimethylsilyl)oxy>-2-methylpentan-1-ol 

Downstream Products

• 623927-76-4 4-(R)-benzyl-3-[(2R,3S,4S,5R)-5-(tert-butyldimethylsilanyloxy)-3-propionyloxy-2,4-dimethylheptanoyl]-oxazolidin-2-one 
• 186489-76-9 1-{(Z)-(1S,2R)-1-[(1R,2R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-butyl]-2-methyl-3-trimethylsilanyloxy-pent-3-enyloxymethyl}-4-methoxy-benzene 
• 171005-61-1 (R)-4-Benzyl-3-((R)-2-{(4S,5R,6S)-6-[(1S,2S,3R,5R,6S,7R,8R)-8-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-6-(4-methoxy-benzyloxy)-1,3,5,7-tetramethyl-4-oxo-decyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-propionyl)-oxazolidin-2-one 
• 186489-75-8 (4R,5S,6R,7R)-7-(t-butyldimethylsilyloxy)-5-[(p-methoxybenzyl)oxy]-4,6-dimethylnonan-3-one 

Relevant academic research and scientific papers

Substrate recognition and channeling of monomodules from the pikromycin polyketide synthase

The unique ability of the pikromycin (Pik) polyketide synthase to generate 12- and 14-membered ring macrolactones presents an opportunity to explore the fundamental processes underlying polyketide synthesis, specifically the mechanistic details of the cha

Enantiospecific synthesis of tetrasubstituted δ-lactones

For investigations concerning the selectivity of polyketide synthases (PKSs) which have been rationally engineered through genetic techniques the synthesis of substituted δ-lactones is of great importance. An enantiospecific route towards eight of the possible sixteen stereoisomers was developed which is also readily adaptable for the introduction of alkyl modifications and isotopic labels.

General strategies toward the syntheses of macrolide antibiotics. The total syntheses of 6-deoxyerythronolide B and oleandolide

The asymmetric syntheses of 6-deoxyerythronolide B (1) and oleandolide (2) have been achieved, each in 18 linear steps. These syntheses demonstrate the utility of chiral β-keto imide building block 3 as a versatile building block for the aldol-based assemblage of polypropionate-derived natural products.