186501-22-4

Upstream product

• 21615-34-9 2-Methoxybenzoyl chloride 
• 548-93-6 3-hydroxyanthranilic acid 
• 1310944-70-7 methyl 2-(2-methoxyphenyl)benzo[d]oxazole-4-carboxylate 
• 17672-21-8 2-amino-3-hydroxy-benzoic acid methyl ester 
• 135-02-4 ortho-anisaldehyde 

Downstream Products

• 906095-21-4 2-(2-hydroxyphenyl)benzo[d]oxazole-4-carboxylic acid 
• 186501-23-5 3-Hydroxy-2-{[2-(2-methoxy-phenyl)-benzooxazole-4-carbonyl]-amino}-benzoic acid methyl ester 

Relevant academic research and scientific papers

Synthesis of caboxamycin and its derivatives using eco-friendly oxidation

The reaction of 3-hydroxyanthranilic acid or methyl 3-hydroxyanthranilate with O-benzylsalicylaldehyde in xylenes gave benzoxazole derivatives, which lead to a novel benzoxazole antibiotic, caboxamycin via debenzylation or demethylation in good yield, in

Benzoxazole carboxamides for treating CINV and IBS-D

Compounds of formulae I and II: are disclosed as 5-HT3 inhibitors. Those compounds that exhibit central activity are useful in treating CINV; those that inhibit peripheral receptors are useful to treat IBS-D.

The total synthesis of UK-1

A concise, five-step total synthesis of UK-1, a novel bis(benzoxazole) metabolite of Streptomyces sp. 517-02, was accomplished. The methyl ether of UK-1 was also synthesized in 3 steps using the same methodology. Both syntheses are accomplished by the seq