18651-57-5

Basic information

• Product Name: Octane, 2-chloro-, (R)-
• CAS NO: 18651-57-5
• Molecular Formula: C8H17Cl
• Molecular Weight: 148.676
• Mol File: 18651-57-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Octane, 2-chloro-, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Octane, 2-chloro-, (R)-(18651-57-5)
• EPA Substance Registry System: Octane, 2-chloro-, (R)-(18651-57-5)

Safety Data

• Hazardous Substances Data: 18651-57-5(Hazardous Substances Data)

Upstream product

• 191331-78-9 (S)-2-octyl chloroformate 
• 6169-06-8 (S)-2-Octanol 
• 67-66-3 chloroform 
• 7647-01-0 hydrogenchloride 
• 60-29-7 diethyl ether 
• 545-06-2 trichloroacetonitrile 
• 1174658-46-8 C₂₀H₃₂O₇S 
• 1174658-47-9 C₁₇H₂₃NO₃S 
• 34817-25-9 (S)-1-methylheptyl tosylate 
• 1309251-35-1 C₁₃H₂₁NO₃S 
• 5978-70-1 (R)-Octan-2-ol 
• 56772-63-5 (R)-octan-2-yl methanesulfonate 
• 101432-92-2 chloro-bis-((S)-1-methyl-heptyloxy)-borane 
• 10026-13-8 phosphorus pentachloride 

Downstream Products

• 53970-41-5 (S)-(+)-(2-Octyl)-(p-tolyl)-sulfid 
• 1573-04-2 1-methyl-4-(octan-2-ylsulfonyl)benzene 
• 3004-93-1 2-methyloctanoic acid 

Relevant articles and documents

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Clarification of the stereochemical course of nucleophilic substitution of arylsulfonate-based nucleophile assisting leaving groups

(Chemical Equation Presented) Secondary alcohols modified as tosylates, PEG-sulfonates, or quisylates undergo inversion of configuration at the reacting center when treated with lithium halide in acetone at reflux, where the PEG-sulfonates and quisylates are substantially more reactive. In sterically hindered cases, elimination is a competing process. In contrast, when treated with TiCl4, simple secondary sulfonates give chloride products with partial inversion of configuration. Any observed retention of configuration in a given alkyl sulfonate substrate under these conditions is likely due to neighboring group participation or diastereoselective attack on a carbocation (or ion pair) rather than an SNi mechanism.