186538-15-8Relevant articles and documents
Synthesis and biological evaluation of novel allophenylnorstatine-based HIV-1 protease inhibitors incorporating high affinity P2-ligands
Ghosh, Arun K.,Gemma, Sandra,Simoni, Elena,Baldridge, Abigail,Walters, D. Eric,Ide, Kazuhiko,Tojo, Yasushi,Koh, Yasuhiro,Amano, Masayuki,Mitsuya, Hiroaki
scheme or table, p. 1241 - 1246 (2010/06/15)
A series of stereochemically defined cyclic ethers as P2-ligands were incorporated in an allophenylnorstatine-based isostere to provide a new series of HIV-1 protease inhibitors. Inhibitors 3b and 3c, containing conformationally constrained cyclic ethers,
Tripeptide compounds and anti-AIDS medicine
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, (2008/06/13)
A novel tripeptide compound represented by the following general formula (I) exhibiting superior HIV protease inhibition activity, and an anti-AIDS medicine comprising this compound as an effective component and a pharmaceutically acceptable salt thereof.