478697-33-5Relevant academic research and scientific papers
Synthesis and biological evaluation of novel allophenylnorstatine-based HIV-1 protease inhibitors incorporating high affinity P2-ligands
Ghosh, Arun K.,Gemma, Sandra,Simoni, Elena,Baldridge, Abigail,Walters, D. Eric,Ide, Kazuhiko,Tojo, Yasushi,Koh, Yasuhiro,Amano, Masayuki,Mitsuya, Hiroaki
scheme or table, p. 1241 - 1246 (2010/06/15)
A series of stereochemically defined cyclic ethers as P2-ligands were incorporated in an allophenylnorstatine-based isostere to provide a new series of HIV-1 protease inhibitors. Inhibitors 3b and 3c, containing conformationally constrained cyclic ethers,
