18656-40-1

Usage

Chemical structure

A phospholipid molecule consisting of a glycerol backbone, two lauric acid chains, a choline group, and a phosphate group.

Industry applications

Commonly used in the pharmaceutical and cosmetic industries.

Emulsifying properties

Acts as an emulsifier, helping to mix water and oil together.

Moisturizing properties

Provides moisturizing benefits, making it useful in cosmetic products.

Surfactant properties

Functions as a surfactant, reducing surface tension and allowing for better spreading and absorption.

Role in lipid bilayers

Plays an important role in the formation of lipid bilayers and cell membranes.

Drug delivery

Used in the production of liposomes for drug delivery, providing a stable and controlled release of pharmaceuticals.

Research and development

May have applications in research and development, particularly in the study of lipid interactions and membrane dynamics.

Molecular weight

Approximately 707.01 g/mol (calculated from the molecular formula)

Solubility

Soluble in organic solvents, such as chloroform and methanol, but insoluble in water.

Stability

Generally stable under normal conditions, but sensitive to extreme temperatures, pH levels, and exposure to light.

Safety

Generally considered safe for use in pharmaceutical and cosmetic applications, but potential for irritation or allergic reactions in some individuals.

InChI:InChI=1/C32H64NO8P/c1-6-8-10-12-14-16-18-20-22-24-31(34)38-28-30(29-40-42(36,37)39-27-26-33(3,4)5)41-32(35)25-23-21-19-17-15-13-11-9-7-2/h30H,6-29H2,1-5H3

Upstream product

• 4167-02-6 2-bromoethylphosphoric acid dichloride 
• 17598-94-6 glyceryl dilaurate 
• 75-50-3 trimethylamine 
• 2146-71-6 vinyl laurate 
• 34688-34-1 glycerolcholine phosphate 
• 55357-38-5 choline tosylate 
• 143-07-7 lauric acid 

Relevant academic research and scientific papers

Method for preparing difatty acyl phosphatidylcholine by solid-phase reaction

The invention relates to a method for preparing difatty acyl phosphatidylcholine by a solid-phase reaction. Glycerol phosphatidylcholine is subjected to wet-process loading by using a high-activity solid adsorbent, and then a condensation reaction is carried out on the glycerol phosphatidylcholine with fatty acid to obtain the difatty acyl phosphatidylcholine. The method comprises the following steps: dissolving glyceryl phosphatidylcholine in an organic solvent, adding a high-activity solid adsorbent, carrying out adsorbing dispersion while stirring, removing the organic solvent by vacuum evaporation, and carrying out vacuum drying on the obtained solid-phase loaded mixed material; dissolving fatty acid in an organic solvent, adding a condensation coupling agent, carrying out heating reflux to prepare active ester of fatty acid, adding the solid-phase loaded glyceryl phosphatidylcholine, and continuing reflux to prepare a difatty acyl phosphatidylcholine crude product; and carrying out filtering to recover the high-activity solid adsorbent, desolventizing mother liquor, pulping a crude product by using an organic solvent, and carrying out recrystallizing to obtain the high-puritydifatty acyl phosphatidylcholine. According to the method, the reaction yield reaches 65% or above, the product purity reaches 99% or above, the process is simple, the production period is short, andindustrial production is easy to achieve.

1,2-Diacrylglycerol and wherein the intermediate preparation method

The invention discloses a preparation method for diacylglycero and an intermediate thereof. The preparation method for diacylglycero comprises the following steps: in an ether solvent and/or an alcohol solvent, in the present of an alkali, performing hydrolysis reaction on a compound shown as a formula 5, so as to obtain diacylglycero which is 1 shown in a formula 1. R in the formula 5 and 5 is C14-C18 saturated or unsaturated aliphatic acyl. The preparation method is cheap in raw materials, mild in reaction conditions, safe in operation, simple in postprocessing operation, high in reaction conversion rate, high in yield and suitable for large-scale production.

Process for the production of phospholipids

A new enzymatic process for preparing 1,2-diacylated phospholipids using an enzyme preparation possessing phospholipase activity towards acylation at the sn-1 and sn-2 sites in a microaqueous reaction system. More particularly, the 1,2-diacyl-phospholipids produced according to the esterification/transesterification process are obtainable in high yield and purity and carry identical desired carboxylic acid, preferably fatty acid, acyl groups at the sn-1 and sn-2 positions. The process involves esterification/transesterification (acylation) of a glycerophospholipid, preferably glycerophosphoryl choline (GPC) with a desired carboxylic acid, preferably fatty acid, or their derivatives in the presence of the above mentioned appropriate enzyme preparation. The process of the invention further relates to a process for the production of 1-acyl-2-lyso-glycerophospholipid, preferably 2-lyso-PC by reacting glycerophospholipid, preferably glycerophosphoryl choline (GPC) with a desired carboxylic acid, preferably fatty acid, or their derivatives in the presence of a sn-1 specific phospholipase (PLA1 or PLA1,2) and a solvent, in a microaqueous medium.

Acoustic shock wave targeting of drug delivery in patients

Acoustic shock waves generated outside a patient's body are focused upon selected target zones within a patient's body to cause release of biologically active substances from liposomes administered to the patient. The procedures may serve to increase cell uptake of drugs and reduce systemic toxicity.