186606-12-2

Upstream product

• 65-85-0 benzoic acid 
• 118-29-6 2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione 
• 136918-14-4 phthalimide 
• 106352-01-6 3-(phthalimidomethyl)benzoic acid 

Downstream Products

• 155873-30-6 m-phthalimidomethyl-p-acetylbenzanilide 
• 1165852-01-6 C₂₆H₂₁BrN₂O₆ 
• 875557-17-8 3-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-benzoic acid [1-phenyl-meth-(E)-ylidene]-hydrazide 
• 875557-11-2 3-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-benzoic acid hydrazide 

Relevant academic research and scientific papers

ANTIBACTERIAL AGENTS

The application concerns compounds for use as antibacterial agents, processes for their preparation, and compositions comprising said agents, wherein said compounds have formula (VI) and r, p, R1, R2, R3 and R4

Synthesis, characterization and biological activity of 1,3,4-substituted 2-azetidinones

Amido/imido alcohol/2-phenyl-3-hydroxyethylquinazolin-4 (3H) -one 1 on treatment with benzoic acid in the presence of cone. H2SO4 yields m-(aralkylamido/imidoalkyl/2-phenyl-3-ethyl-3H-4-oxoquinazolinyl) benzoic acids 2. The acid chloride of 2 on reaction with hydrazine hydrate affords m-(aralkylamido/imidoalkyl/2-phenyl-3-ethyl-3H-4-oxo-quinazolinyl) benzoic acid hydrazides 4 which on condensation with an aromatic aldehyde in acetic acid gives m-(aralkylamido/imidoalkyl/2-phenyl-3-ethyl-3H-4-oxo- quinazolinyl) benzoic acid hydrazones 5. Compounds 5 undergo cyclization with phenoxy acetic acid in the presence of thionyl chloride in dry benzene to furnish 1-[m-(aralkylamido/imidoalkyl/2-phenyl-3-ethyl-3H-4-oxo-quinazolinyl- benzamido)]-3-phenoxy-4-phenyl-2-azetidinones 6. The antiviral and antifungal activities of 6 have been reported.