106352-01-6

Usage

Uses

Used in Pharmaceutical Industry:
3-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YLMETHYL)-BENZOIC ACID is used as a building block for the synthesis of various organic compounds, particularly in the development of pharmaceuticals. Its unique structure may contribute to the creation of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 3-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YLMETHYL)-BENZOIC ACID is utilized as a component in the synthesis of agrochemicals, potentially enhancing the effectiveness of pesticides or other agricultural products.
Used in Research and Development:
3-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YLMETHYL)-BENZOIC ACID serves as a subject of research in medicine and biology, where its potential applications and biological activities are being explored to understand its full scope of utility across various industries.

InChI:InChI=1/C16H11NO4/c18-14-12-6-1-2-7-13(12)15(19)17(14)9-10-4-3-5-11(8-10)16(20)21/h1-8H,9H2,(H,20,21)/p-1

Upstream product

• 118-29-6 2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione 
• 65-85-0 benzoic acid 
• 136918-14-4 phthalimide 

Downstream Products

• 186606-12-2 3-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-benzoyl chloride 
• 952424-11-2 3-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-benzaldehyde 
• 875557-17-8 3-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-benzoic acid [1-phenyl-meth-(E)-ylidene]-hydrazide 
• 875557-11-2 3-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-benzoic acid hydrazide 
• 491836-78-3 2-(3-hydroxymethyl-benzyl)-isoindole-1,3-dione 
• 155873-30-6 m-phthalimidomethyl-p-acetylbenzanilide 

Relevant academic research and scientific papers

Design and synthesis of a biologically active antibody mimic based on an antibody-antigen crystal structure

We have used the crystal structure of an N9 sialidase (antigen)-NC41 (antibody) complex to design a low molecular weight compound that mimics the binding function of the macromolecular antibody. The components of recognition between the antibody and the protein antigen have been analyzed from the energy-refined crystal complex. From this analysis, four amino acid residues on the antibody binding surface, which make direct contact with the active-site loop 368-370 of the antigen, have been identified as contributing the majority of the binding energy of the protein. The designed target compound, a constrained cyclic peptide, which mimics the receptor-bound conformation of these amino acids, has been synthesized and found to inhibit N9 sialidase activity, with a K(i) of 1 x 10-4 M.

ANTIBACTERIAL AGENTS

The application concerns compounds for use as antibacterial agents, processes for their preparation, and compositions comprising said agents, wherein said compounds have formula (VI) and r, p, R1, R2, R3 and R4

Synthesis, characterization and biological activity of 1,3,4-substituted 2-azetidinones

Amido/imido alcohol/2-phenyl-3-hydroxyethylquinazolin-4 (3H) -one 1 on treatment with benzoic acid in the presence of cone. H2SO4 yields m-(aralkylamido/imidoalkyl/2-phenyl-3-ethyl-3H-4-oxoquinazolinyl) benzoic acids 2. The acid chloride of 2 on reaction with hydrazine hydrate affords m-(aralkylamido/imidoalkyl/2-phenyl-3-ethyl-3H-4-oxo-quinazolinyl) benzoic acid hydrazides 4 which on condensation with an aromatic aldehyde in acetic acid gives m-(aralkylamido/imidoalkyl/2-phenyl-3-ethyl-3H-4-oxo- quinazolinyl) benzoic acid hydrazones 5. Compounds 5 undergo cyclization with phenoxy acetic acid in the presence of thionyl chloride in dry benzene to furnish 1-[m-(aralkylamido/imidoalkyl/2-phenyl-3-ethyl-3H-4-oxo-quinazolinyl- benzamido)]-3-phenoxy-4-phenyl-2-azetidinones 6. The antiviral and antifungal activities of 6 have been reported.

Synthesis and biological activity of isoquinolinyl benzimidazoles

Condensation of benzoic acid with amidoalcohols in presence of conc. H2SO4 furnishes m-(amidoalkyl)-benzoic acids 1 which on treatment with benzoin in polyphosphoric acid give 3,4-diphenyl-7-amidoalkyl-coumarins 2 in excellent yields