186753-95-7

Upstream product

• 591-50-4 iodobenzene 
• 2537-48-6 diethyl 1-cyanomethylphosphonate 
• 123-11-5 4-methoxy-benzaldehyde 
• 1369584-53-1 C₁₉H₂₂O₂Si 

Downstream Products

• 40591-05-7 3-(4-methoxyphenyl)-3-phenylpropanenitrile 
• 17684-11-6 3-(4-anisyl)cinnamic acid 
• 101283-45-8 3ξ-(4-methoxy-phenyl)-3ξ-phenyl-acrylic acid amide 
• 101292-71-1 3-(4-methoxy-phenyl)-3-phenyl-allylamine 
• 51431-54-0 2-(p-methoxyphenyl)-2-phenylethylamine 
• 69549-79-7 3-(4-methoxy-phenyl)-3-phenyl-propylamine 
• 22101-03-7 3-(4-methoxyphenyl)-3-phenylpropionamide 

Relevant academic research and scientific papers

New approaches towards the synthesis of alkenes using the Horner-Wadsworth-Emmons (HWE) reaction as the key step

Leading from our work in asymmetric alkene synthesis it was discovered that the alkenylatio of aldehydes with phosphonates proceeds smoothly at room temperature in the absence of Lewis acidusing triethylamine as the base if the reaction is carried out at a pressure of 8 kbar. Based on this protoco a new domino process was developed, combining the HWE reaction with a Heck coupling, thus allowing the one pot synthesis of trisubstituted alkenes.

Synthesis of acrylonitriles through an FeCl3-catalyzed domino propargylic substitution/aza-Meyer-Schuster rearrangement sequence

Nontoxic cyanide source: An unprecedented route to acrylonitriles by employing propargylic alcohols and para-tolylsulfonohydrazide as a combined cyano source has been developed (see scheme). This efficient and practical cyanation reaction proceeds through an FeCl3-catalyzed domino propargylic substitution/aza-Meyer-Schuster rearrangement sequence, the rearrangement process of which is reported for the first time. Copyright