New approaches towards the synthesis of alkenes using the Horner-Wadsworth-Emmons (HWE) reaction as the key step

Article abstract of DOI:10.1080/10426509908546210

Leading from our work in asymmetric alkene synthesis it was discovered that the alkenylatio of aldehydes with phosphonates proceeds smoothly at room temperature in the absence of Lewis acidusing triethylamine as the base if the reaction is carried out at a pressure of 8 kbar. Based on this protoco a new domino process was developed, combining the HWE reaction with a Heck coupling, thus allowing the one pot synthesis of trisubstituted alkenes.

Full text of DOI:10.1080/10426509908546210

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Phosphorus, Sulfur, and
Silicon and the Related
Elements
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New Approaches
towards the Synthesis
of Alkenes using the
Horner-Wadsworth-
Emmons (HWE) Reaction
as the Key Step
Kerstin Bodman , Shenay Has-Becker &
Oliver Reiser
a Department of Organic Chemistry ,
University of Regensburg,
Universitätsstr. , 31, D-93053 Regensburg
b Department of Organic Chemistry ,
University of Regensburg,
Universitätsstr. , 31, D-93053 Regensburg
c Department of Organic Chemistry ,
University of Regensburg,
Universitätsstr. , 31, D-93053 Regensburg
Published online: 17 Mar 2008.
To cite this article: Kerstin Bodman , Shenay Has-Becker & Oliver Reiser
(1999) New Approaches towards the Synthesis of Alkenes using the
Horner-Wadsworth-Emmons (HWE) Reaction as the Key Step, Phosphorus,

Sulfur, and Silicon and the Related Elements, 144:1, 173-176, DOI:
10.1080/10426509908546210
To link to this article: http://dx.doi.org/10.1080/10426509908546210
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