1868-88-8

Usage

Chemical Properties

Light yellow solid

InChI:InChI=1/C14H9ClFN/c15-11-7-10(5-6-12(11)16)14-8-9-3-1-2-4-13(9)17-14/h1-8,17H

Upstream product

• 729-73-7 4-Fluor-3-chlor-acetophenon-phenylhydrazon 
• 2923-66-2 3-chloro-4-fluoroacetophenone 
• 100-63-0 phenylhydrazine 

Downstream Products

• 77445-31-9 2-(3-Chloro-4-fluoro-phenyl)-3-piperidin-1-ylmethyl-1H-indole 
• 77445-30-8 2-(3-Chloro-4-fluoro-phenyl)-3-morpholin-4-ylmethyl-1H-indole 
• 77445-92-2 2-(3-chloro-4-fluorophenyl)-3-indolylglyoxalyl chloride 
• 77445-29-5 [2-(3-Chloro-4-fluoro-phenyl)-1H-indol-3-ylmethyl]-dimethyl-amine 
• 77445-28-4 [2-(3-Chloro-4-fluoro-phenyl)-1H-indol-3-ylmethyl]-diethyl-amine 
• 109271-92-3 3-formyl-2-(3-chloro-4-fluorophenyl)indole 
• 77445-62-6 2-[2-(3-Chloro-4-fluoro-phenyl)-1H-indol-3-yl]-N,N-dimethyl-2-oxo-acetamide 
• 77445-61-5 2-[2-(3-Chloro-4-fluoro-phenyl)-1H-indol-3-yl]-N,N-diethyl-2-oxo-acetamide 
• 77445-85-3 2-(3-Chloro-4-fluoro-phenyl)-3-(2-morpholin-4-yl-ethyl)-1H-indole 
• 77445-64-8 1-[2-(3-Chloro-4-fluoro-phenyl)-1H-indol-3-yl]-2-piperidin-1-yl-ethane-1,2-dione 
• 77445-63-7 1-[2-(3-Chloro-4-fluoro-phenyl)-1H-indol-3-yl]-2-morpholin-4-yl-ethane-1,2-dione 
• 77445-73-9 1-[2-(3-Chloro-4-fluoro-phenyl)-1H-indol-3-yl]-2-(4-{2-[2-(3-chloro-4-fluoro-phenyl)-1H-indol-3-yl]-2-oxo-acetyl}-piperazin-1-yl)-ethane-1,2-dione 
• 109271-97-8 C₁₆H₁₂ClFN₄S 
• 109272-18-6 2-{[1-[2-(3-Chloro-4-fluoro-phenyl)-1H-indol-3-yl]-meth-(Z)-ylidene]-hydrazono}-5-[1-(4-fluoro-phenyl)-meth-(E)-ylidene]-thiazolidin-4-one 

Relevant academic research and scientific papers

Green approach for the synthesis of 3-methyl-1-phenyl-4-((2-phenyl-1H-indol 3-yl)methylene)-1H-pyrazole-5(4H)-ones and their DNA Cleavage, antioxidant, and antimicrobial activities

3-Methyl-1-phenyl-4-((2-phenyl-1H-indol-3-yl)methylene)-1H-pyrazol-5(4H)-ones (5a-i) was prepared by the condensation reaction of different 3-formyl-2-phenylindole derivatives (2a-i) and 3-methyl-1-phenyl-2-pyrazoline-5-one in quantitative yield by applying various green synthetic methods as grinding, microwave irradiation using different catalysts under solvent-free mild reaction conditions with high product yields. The structures of the synthesized compounds were characterized on the basis of elemental analysis, infrared, 1HNMR, 13C NMR, and mass spectral data. The synthesized compounds were screened for free radical scavenging, antimicrobial, and DNA cleavage activities. Most of the tested compounds belonging to the 3-methyl-1-phenyl-4-((2-phenyl-1H-indol-3-yl)methylene)-1H-pyrazol-5(4H)-ones series exhibited promising activities.

SYNTHESIS AND MASS SPECTRAL STUDIES OF FLUORINE CONTAINING 5a, 7b, 12a, 14b-TETRAHYDROBISINDOLO BENZO DIFURANS

2:1 Cycloadducts (-H2) are formed when various fluorinated 2-arylindoles are stirred with p-benzoquinone in acidic medium and are identified as dimers of the type 5a, 7b, 12a, 14b-tetrahydrobisindolo benzo difurans.All the synthesized compounds have been characterized by their analytical and spectral (IR, PMR, 19F NMR and Mass) data.