1868-88-8

Basic information

• Product Name: 2-(3-CHLORO-4-FLUOROPHENYL)INDOLE
• Synonyms: 2-(3-CHLORO-4-FLUOROPHENYL)-1H-INDOLE;2-(3-CHLORO-4-FLUOROPHENYL)INDOLE;2-(3-Chloro-4-fluorophenyl)indole 97%;2-(3-Chloro-4-fluorophenyl)indole97%;2-(3-Chloro-4-fluorophenyl)indole ,98%
• CAS NO: 1868-88-8
• Molecular Formula: C₁₄H₉ClFN
• Molecular Weight: 245.68
• Product Categories: Indole
• Mol File: 1868-88-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 170-173°C
• Boiling Point: 420.462 °C at 760 mmHg
• Flash Point: 208.088 °C
• Appearance: solid
• Density: 1.34 g/cm³
• Vapor Pressure: 6.86E-07mmHg at 25°C
• Refractive Index: 1.664
• CAS DataBase Reference: 2-(3-CHLORO-4-FLUOROPHENYL)INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-CHLORO-4-FLUOROPHENYL)INDOLE(1868-88-8)
• EPA Substance Registry System: 2-(3-CHLORO-4-FLUOROPHENYL)INDOLE(1868-88-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38
• Safety Statements: 36/37/39-26
• Hazardous Substances Data: 1868-88-8(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow solid

InChI:InChI=1/C14H9ClFN/c15-11-7-10(5-6-12(11)16)14-8-9-3-1-2-4-13(9)17-14/h1-8,17H

Upstream product

• 729-73-7 4-Fluor-3-chlor-acetophenon-phenylhydrazon 
• 2923-66-2 3-chloro-4-fluoroacetophenone 
• 100-63-0 phenylhydrazine 

Downstream Products

• 77445-29-5 [2-(3-Chloro-4-fluoro-phenyl)-1H-indol-3-ylmethyl]-dimethyl-amine 
• 109271-92-3 3-formyl-2-(3-chloro-4-fluorophenyl)indole 
• 77445-62-6 2-[2-(3-Chloro-4-fluoro-phenyl)-1H-indol-3-yl]-N,N-dimethyl-2-oxo-acetamide 
• 77445-61-5 2-[2-(3-Chloro-4-fluoro-phenyl)-1H-indol-3-yl]-N,N-diethyl-2-oxo-acetamide 
• 77445-85-3 2-(3-Chloro-4-fluoro-phenyl)-3-(2-morpholin-4-yl-ethyl)-1H-indole 
• 77445-64-8 1-[2-(3-Chloro-4-fluoro-phenyl)-1H-indol-3-yl]-2-piperidin-1-yl-ethane-1,2-dione 
• 77445-63-7 1-[2-(3-Chloro-4-fluoro-phenyl)-1H-indol-3-yl]-2-morpholin-4-yl-ethane-1,2-dione 
• 77445-73-9 1-[2-(3-Chloro-4-fluoro-phenyl)-1H-indol-3-yl]-2-(4-{2-[2-(3-chloro-4-fluoro-phenyl)-1H-indol-3-yl]-2-oxo-acetyl}-piperazin-1-yl)-ethane-1,2-dione 
• 109272-19-7 2-{[1-[2-(3-Chloro-4-fluoro-phenyl)-1H-indol-3-yl]-meth-(Z)-ylidene]-hydrazono}-5-[1-pentafluorophenyl-meth-(E)-ylidene]-thiazolidin-4-one 
• 109272-17-5 2-{[1-[2-(3-Chloro-4-fluoro-phenyl)-1H-indol-3-yl]-meth-(Z)-ylidene]-hydrazono}-5-[1-(4-nitro-phenyl)-meth-(E)-ylidene]-thiazolidin-4-one 
• 109272-20-0 5-[1-Benzo[1,3]dioxol-5-yl-meth-(E)-ylidene]-2-{[1-[2-(3-chloro-4-fluoro-phenyl)-1H-indol-3-yl]-meth-(Z)-ylidene]-hydrazono}-thiazolidin-4-one 
• 109272-18-6 2-{[1-[2-(3-Chloro-4-fluoro-phenyl)-1H-indol-3-yl]-meth-(Z)-ylidene]-hydrazono}-5-[1-(4-fluoro-phenyl)-meth-(E)-ylidene]-thiazolidin-4-one 
• 109271-97-8 C₁₆H₁₂ClFN₄S 
• 77445-28-4 [2-(3-Chloro-4-fluoro-phenyl)-1H-indol-3-ylmethyl]-diethyl-amine 

Relevant articles and documents

Green approach for the synthesis of 3-methyl-1-phenyl-4-((2-phenyl-1H-indol 3-yl)methylene)-1H-pyrazole-5(4H)-ones and their DNA Cleavage, antioxidant, and antimicrobial activities

3-Methyl-1-phenyl-4-((2-phenyl-1H-indol-3-yl)methylene)-1H-pyrazol-5(4H)-ones (5a-i) was prepared by the condensation reaction of different 3-formyl-2-phenylindole derivatives (2a-i) and 3-methyl-1-phenyl-2-pyrazoline-5-one in quantitative yield by applying various green synthetic methods as grinding, microwave irradiation using different catalysts under solvent-free mild reaction conditions with high product yields. The structures of the synthesized compounds were characterized on the basis of elemental analysis, infrared, 1HNMR, 13C NMR, and mass spectral data. The synthesized compounds were screened for free radical scavenging, antimicrobial, and DNA cleavage activities. Most of the tested compounds belonging to the 3-methyl-1-phenyl-4-((2-phenyl-1H-indol-3-yl)methylene)-1H-pyrazol-5(4H)-ones series exhibited promising activities.

Synthesis of some new fluorine containing 3-dialkylaminomethyl indoles, 3-indolylglyoxamides and tryptamines

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