186895-24-9Relevant academic research and scientific papers
Enantioselective total synthesis of ligraminol d and ligraminol e
Kumbhar, D. D.,Mane, Baliram B.,Waghmode, Suresh B.
, p. 2285 - 2289 (2019)
As a part of our ongoing research on the synthesis of bioactive constituents or molecules by using an organocatalytic approach, enantioselective total syntheses of ligraminol D and ligraminol E were achieved starting from a commercially available nonchiral aldehyde. Key steps in this synthesis were an asymmetric α-aminoxylation of an aldehyde and a Mitsunobu reaction.
Modular synthesis and biological investigation of 5-hydroxymethyl dibenzyl butyrolactones and related lignans
Davidson, Samuel J.,Pilkington, Lisa I.,Dempsey-Hibbert, Nina C.,El-Mohtadi, Mohamed,Tang, Shiying,Wainwright, Thomas,Whitehead, Kathryn A.,Barker, David
, (2018/11/30)
Dibenzyl butyrolactone lignans are well known for their excellent biological properties, particularly for their notable anti-proliferative activities. Herein we report a novel, efficient, convergent synthesis of dibenzyl butyrolactone lignans utilizing the acyl-Claisen rearrangement to stereoselectively prepare a key intermediate. The reported synthetic route enables the modification of these lignans to give rise to 5-hydroxymethyl derivatives of these lignans. The biological activities of these analogues were assessed, with derivatives showing an excellent cytotoxic profile which resulted in programmed cell death of Jurkat T-leukemia cells with less than 2% of the incubated cells entering a necrotic cell death pathway.
First total synthesis and reassignment of absolute configuration of diosniponol A and B
Yadav,Singh, Vinay K.,Thirupathaiah,Reddy, A. Bal
, p. 4427 - 4429 (2014/08/05)
Enantioselective first total synthesis of diosniponol A and B has been achieved starting from commercially available vanillin. Wittig reaction, Keck allylation, and Prins cyclization reactions are the key steps involved in the target synthesis.
INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME
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Page/Page column 44-45, (2010/02/07)
Compounds of formula (I) are hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) inhibitors, and are useful in therapeutic and prophylactic treatment of persons infected with hepatitis C virus.
An organo-iron mediated chiral synthesis of (+)-(S)-[6]-Gingerol
Le Gall,Lellouche,Beaucourt
, p. 6521 - 6524 (2007/10/02)
A short and efficient synthesis of (+)-(S)-[6]-Gingerol is described. The key step is a highly stereoselective cycloaddition of a nitrile oxide with a chiral iron complexed triene.
Structure and Synthesis of New Phenolic Amides from Piper nigrum L.
Inatani, Reiko,Nakatani, Nobuji,Fuwa, Hidetsugu
, p. 667 - 674 (2007/10/02)
New phenolic amides, N-trans-feruloyl piperidine (4a), N-5-(4-hydroxy-3-methoxyphenyl)-2E,4E-pentadienoyl piperidine (5a) and N-5-(4-hydroxy-3-methoxyphenyl)-2E-pentenoyl piperidine (6a) were isolated from the fruit of white pepper (Piper nigrum L.).The f
