186895-24-9

Upstream product

• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 
• 61292-90-8 ethyl 3-(4-hydroxy-3-methoxyphenyl)propanoate 
• 100-39-0 benzyl bromide 
• 28028-62-8 ethyl ferulate 
• 121-33-5 vanillin 

Downstream Products

• 57371-44-5 3-<4-(benzyloxy)-3-methoxyphenyl>propan-1-ol 
• 30034-49-2 β-(4-benzyloxy-3-methoxyphenyl)propionic acid 
• 69172-20-9 3-(3-methoxy-4-benzyloxyphenyl)propionaldehyde 
• 105245-81-6 3-(4-benzyloxy-3-methoxyphenyl)propionic acid chloride 
• 77795-18-7 N-5-(4-benzyloxy-3-methoxyphenyl)-2E-pentenoyl piperidine 
• 127766-48-7 1-Benzyloxy-2-methoxy-4-(3-nitro-propyl)-benzene 
• 127766-49-8 (R)-3-[2-(4-Benzyloxy-3-methoxy-phenyl)-ethyl]-5-((1E,3E)-penta-1,3-dienyl)-4,5-dihydro-isoxazole 
• 39886-76-5 [6]-gingerol 
• 1616883-92-1 C₃₅H₃₈O₈S 
• 1616883-93-2 C₃₇H₄₂O₆ 
• 1616883-94-3 C₂₈H₃₂O₆ 
• 1443418-27-6 (1S,3R,5S)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,5-epoxy-3-hydroxyheptane 
• 1616883-96-5 C₃₀H₃₁F₃O₅ 

Relevant academic research and scientific papers

Enantioselective total synthesis of ligraminol d and ligraminol e

As a part of our ongoing research on the synthesis of bioactive constituents or molecules by using an organocatalytic approach, enantioselective total syntheses of ligraminol D and ligraminol E were achieved starting from a commercially available nonchiral aldehyde. Key steps in this synthesis were an asymmetric α-aminoxylation of an aldehyde and a Mitsunobu reaction.

Modular synthesis and biological investigation of 5-hydroxymethyl dibenzyl butyrolactones and related lignans

Dibenzyl butyrolactone lignans are well known for their excellent biological properties, particularly for their notable anti-proliferative activities. Herein we report a novel, efficient, convergent synthesis of dibenzyl butyrolactone lignans utilizing the acyl-Claisen rearrangement to stereoselectively prepare a key intermediate. The reported synthetic route enables the modification of these lignans to give rise to 5-hydroxymethyl derivatives of these lignans. The biological activities of these analogues were assessed, with derivatives showing an excellent cytotoxic profile which resulted in programmed cell death of Jurkat T-leukemia cells with less than 2% of the incubated cells entering a necrotic cell death pathway.

First total synthesis and reassignment of absolute configuration of diosniponol A and B

Enantioselective first total synthesis of diosniponol A and B has been achieved starting from commercially available vanillin. Wittig reaction, Keck allylation, and Prins cyclization reactions are the key steps involved in the target synthesis.

INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME

Compounds of formula (I) are hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) inhibitors, and are useful in therapeutic and prophylactic treatment of persons infected with hepatitis C virus.

An organo-iron mediated chiral synthesis of (+)-(S)-[6]-Gingerol

A short and efficient synthesis of (+)-(S)-[6]-Gingerol is described. The key step is a highly stereoselective cycloaddition of a nitrile oxide with a chiral iron complexed triene.

Structure and Synthesis of New Phenolic Amides from Piper nigrum L.

New phenolic amides, N-trans-feruloyl piperidine (4a), N-5-(4-hydroxy-3-methoxyphenyl)-2E,4E-pentadienoyl piperidine (5a) and N-5-(4-hydroxy-3-methoxyphenyl)-2E-pentenoyl piperidine (6a) were isolated from the fruit of white pepper (Piper nigrum L.).The f