186895-45-4

Basic information

• Product Name: Benzenepropanoic acid, 4-(phenylmethoxy)-, ethyl ester
• CAS NO: 186895-45-4
• Molecular Formula: C18H20O3
• Molecular Weight: 284.355
• Mol File: 186895-45-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzenepropanoic acid, 4-(phenylmethoxy)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid, 4-(phenylmethoxy)-, ethyl ester(186895-45-4)
• EPA Substance Registry System: Benzenepropanoic acid, 4-(phenylmethoxy)-, ethyl ester(186895-45-4)

Safety Data

• Hazardous Substances Data: 186895-45-4(Hazardous Substances Data)

Upstream product

• 87030-11-3 ethyl 3-(4-(benzyloxy)phenyl)acrylate 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 53090-45-2 ethyl 3-[4-(benzyloxy)phenyl]-3-oxopropanoate 
• 23795-02-0 3-(4-hydroxy-phenyl)-propionic acid ethyl ester 
• 100-39-0 benzyl bromide 
• 123-08-0 4-hydroxy-benzaldehyde 

Downstream Products

• 61440-45-7 3-[4-(benzyloxy)phenyl]propan-1-ol 
• 850251-73-9 1-(4-(benzyloxy)phenyl)hex-5-en-3-ol 
• 767330-04-1 (-)-(3S)-1-[4-(benzyloxy)phenyl]hex-5-en-3-ol 
• 1337550-58-9 (3S,5S)-3,5-dihydroxy-1-(4-hydroxyphenyl)-7-phenyl-6E-heptane 
• 1187819-84-6 (S)-5-(4-(benzyloxy)phenyl)-3-(tert-butyldimethylsilyloxy)pentan-1-ol 
• 1187819-79-9 (3S)-5-[4-(benzyloxy)phenyl]-3-{[tert-butyl(dimethyl)silyl]oxy}pentanal 
• 1638640-04-6 ({(3S)-1-[4-(benzyloxy)phenyl]hex-5-en-3-yl}oxy)(tert-butyl)(dimethyl)silane 
• 68486-77-1 3-(4-(benzyloxy)phenyl)propanal 
• 1010127-34-0 (2S)-2-{2-[4-(benzyloxy)phenyl]ethyl}oxirane 
• 1401711-88-3 (3R)-1-[4-(benzyloxy)phenyl]hept-6-en-3-ol 
• 1401711-90-7 4-{(1E,5R)-7-[4-(benzyloxy)phenyl]-5-hydroxyhept-1-en-1-yl}phenol 

Relevant articles and documents

One-Pot, Tandem Wittig Hydrogenation: Formal C(sp3)-C(sp3) Bond Formation with Extensive Scope

A one-pot, tandem Wittig hydrogenation of aldehydes with stabilized ylides is reported, representing a formal C(sp3)-C(sp3) bond construction. The tandem reaction operates under mild conditions, is high yielding, and is broad in scope. Chemoselectivity for olefin reduction is observed, and the methodology is demonstrated in the synthesis of lapatinib analogues and a formal synthesis of (±)-cuspareine. Early insights suggest that the chemoselectivity observed in the reduction step is due to partial poisoning of the catalyst, after step one, thus adding to the power of the one-pot procedure.

Synthesis of tetrahydropyranyl diarylheptanoids from Dioscorea villosa

Concise syntheses of four tetrahydropyranyl diarylheptanoids isolated from Dioscorea villosa have been described. The key features include Prins cyclization to construct the tetrahydropyran cores, Keck asymmetric allylation, and Mitsunobu inversion. Optimization of the Prins cyclization conditions in order to minimize racemization has been described. Our syntheses also confirmed the absolute stereochemistry of the natural products.

The first stereoselective total synthesis of a naturally occurring bioactive diarylheptanoid, (3R,6E)-1,7-bis(4-hydroxyphenyl)hept-6-en-3-ol, through two different approaches

The stereoselective total synthesis of a naturally occurring bioactive diarylheptanoid, (3R,6E)-1,7-bis(4-hydroxyphenyl)hept-6-en-3-ol, has been accomplished starting from 4-hydroxybenzaldehyde through two different approaches involving Wittig olefination