186895-63-6

Upstream product

• 186895-59-0 ethyl (2E,4R,5R,6E,8S)-5-(tert-butyldimethylsilyloxy)-2,4,6,8-tetramethyl-10-phenyl-2,6-decadienoate 
• 186895-61-4 (2E,4R,5R,6E,8S)-5-(tert-butyldimethylsilyloxy)-10-phenyl-2,4,6,8-tetramethyl-2,6-decadienal 
• 186895-60-3 (2E,4R,5R,6E,8S)-5-(tert-butyldimethylsilyloxy)-2,4,6,8-tetramethyl-10-phenyl-2,6-decadienol 
• 186895-58-9 (2S,3R,4E,6S)-3-(tert-butyldimethylsilyloxy)-2,4,6-trimethyl-8-phenyl-4-octanal 
• 186895-52-3 ethyl (2E,4S)-2,4-dimethyl-6-phenyl-2-hexenoate 
• 186895-55-6 (3R,4R,5E,7S)-3,5,7-trimethyl-9-phenyl-1,5-nonadien-4-ol 
• 186895-54-5 (2E,4S)-2,4-dimethyl-6-phenyl-2-hexen-1-al 
• 186895-53-4 (2E,4S)-2,4-dimethyl-6-phenyl-2-hexen-ol 
• 186895-57-8 (2RS,3R,4R,5E,7S)-4-(tert-butyldimethylsilyloxy)-1,2-dihydroxy-3,5,7-trimethyl-9-phenyl-5-nonene 
• 186895-56-7 (3R,4R,5E,7S)-4-(tert-butyldimethylsilyloxy)-3,5,7-trimethyl-9-phenyl-1,5-nonadiene 
• 186895-62-5 (1E,3E,5R,6R,7E,9S)-1-iodo-3,5,7,9-tetramethyl-6-(t-butyldimethylsilyloxy)-11-phenyl-1,3,7-undecatriene 

Relevant academic research and scientific papers

Total synthesis of stipiamide and designed polyenes as new agents for the reversal of multidrug resistance

The synthesis of (-)-stipiamide (1) is reported together with the designed enynes 2 (6,7-dehydrostipiamide) and 3 that are now shown to reverse the multidrug resistance (MDR) of human breast cancer cells (MCF-7adrR). Stipiamide was assembled using a Still