186910-20-3

Upstream product

• 247107-64-8 (2S,3R,4S,5S,6R,9S,11S)-2-((2S,3S)-7-Bromo-2-hydroxy-3-methyl-hept-6-ynyl)-9-ethyl-4-hydroxy-3,5,11-trimethyl-1-oxa-7-aza-spiro[5.5]undecan-8-one 
• 275805-40-8 C₃₈H₅₁IN₄O₈ 
• 99438-30-9 (Z)-(+)-crotyldiisopinocampheyl borane 
• 247107-71-7 (S)-1-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-3-(3-hydroxy-phenyl)-propionyl]-hexahydro-pyridazine-3-carboxylic acid (E)-(S)-4-iodo-1-((E)-2-iodo-1-methyl-vinyl)-but-3-enyl ester 
• 247107-63-7 (2S,3S,4S,5S,6R,9S,11S)-2-[(2S,3S)-7-Bromo-2-(tert-butyl-dimethyl-silanyloxy)-3-methyl-hept-6-ynyl]-9-ethyl-3,5,11-trimethyl-4-triethylsilanyloxy-1-oxa-7-aza-spiro[5.5]undecan-8-one 
• 247107-61-5 (2S,3S,4S,5S,6R,9S,11S)-2-[(2S,3S)-2-(tert-Butyl-dimethyl-silanyloxy)-3-methyl-hept-6-ynyl]-9-ethyl-3,5,11-trimethyl-4-triethylsilanyloxy-1-oxa-7-aza-spiro[5.5]undecan-8-one 
• 247107-62-6 (2S,3S,4S,5S,6R,9S,11S)-4-(tert-Butyl-dimethyl-silanyloxy)-2-[(2S,3S)-2-(tert-butyl-dimethyl-silanyloxy)-3-methyl-hept-6-ynyl]-9-ethyl-3,5,11-trimethyl-1-oxa-7-aza-spiro[5.5]undecan-8-one 
• 247107-60-4 (4S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-6-((2S,3S,4S,5S,6R,9S,11S)-9-ethyl-3,5,11-trimethyl-8-oxo-4-triethylsilanyloxy-1-oxa-7-aza-spiro[5.5]undec-2-yl)-4-methyl-hexanal 
• 247107-73-9 (S)-1-[(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-(3-hydroxy-phenyl)-propionyl]-hexahydro-pyridazine-3-carboxylic acid (E)-(S)-4-iodo-1-((E)-2-iodo-1-methyl-vinyl)-but-3-enyl ester 
• 247107-81-9 (4S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-6-[(2S,3S,4S,5S,6R,9S,11S)-4-(tert-butyl-dimethyl-silanyloxy)-9-ethyl-3,5,11-trimethyl-8-oxo-1-oxa-7-aza-spiro[5.5]undec-2-yl]-4-methyl-hexanal 
• 247107-66-0 (2S,3S,4S,5S,6R,9S,11S)-2-[(2S,3S)-2-(tert-Butyl-dimethyl-silanyloxy)-3-methyl-pent-4-enyl]-9-ethyl-3,5,11-trimethyl-4-triethylsilanyloxy-1-oxa-7-aza-spiro[5.5]undecan-8-one 
• 275805-46-4 (E)-(4S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-6-[(2S,3S,4S,5S,6R,9S,11S)-4-(tert-butyl-dimethyl-silanyloxy)-9-ethyl-3,5,11-trimethyl-8-oxo-1-oxa-7-aza-spiro[5.5]undec-2-yl]-4-methyl-hex-2-enal 
• 247107-59-1 (2R,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-4-((2S,3S,4S,5S,6R,9S,11S)-9-ethyl-3,5,11-trimethyl-8-oxo-4-triethylsilanyloxy-1-oxa-7-aza-spiro[5.5]undec-2-yl)-2-methyl-butyraldehyde 
• 247107-80-8 (2S,3S,4S,5S,6R,9S,11S)-2-((2S,3S)-7-Bromo-3-methyl-2-trimethylsilanyloxy-hept-6-ynyl)-9-ethyl-3,5,11-trimethyl-4-trimethylsilanyloxy-1-oxa-7-aza-spiro[5.5]undecan-8-one 

Downstream Products

• 187148-13-6 (-)-sanglifehrin A 

Relevant academic research and scientific papers

Total synthesis of sanglifehrin A

The immunosuppressive agent sanglifehrin A has been prepared for the first time by total synthesis. The construction of the macrocyclic unit of the target molecule was achieved through a selective intramolecular Stille coupling, and the spirolactam unit b