187039-58-3Relevant articles and documents
A short synthesis of an important precursor to a new class of bicyclic β-lactamase inhibitors
Bellettini, John R.,Miller, Marvin J.
, p. 167 - 168 (1997)
A short synthesis of an important precursor to known bicyclic β-lactamase inhibitors is described. The synthesis uses commercially available trans-3-hydroxy-L-proline 1. Protection of the amino group followed by formation of the hydroxamate and cyclization using Mitsunobu conditions afforded bicyclic β-lactam 4 in three steps in 53% overall yield.
