187039-59-4Relevant academic research and scientific papers
First synthesis of 2,6-diazabicyclo[3.2.0]heptane derivatives
Napolitano, Carmela,Borriello, Manuela,Cardullo, Francesca,Donati, Daniele,Paio, Alfredo,Manfredini, Stefano
scheme or table, p. 7280 - 7282 (2010/03/03)
The first synthesis of 6-phenyl-2,6-diazabicyclo[3.2.0]heptane 1 and its orthogonally protected precursor 2 is herein reported. Our strategy enables to chemically address the two nitrogen atoms of 2,6-diazabicyclo[3.2.0]heptane core individually and selectively, thus allowing rapid access to several subsets of widely substituted fused azetidines.
Structure-based design of β-lactamase inhibitors. 2. Synthesis and evaluation of bridged sulfactams and oxamazins
Hubschwerlen, Christian,Angehrn, Peter,Gubernator, Klaus,Page, Malcolm G. P.,Specklin, Jean-Luc
, p. 3972 - 3975 (2007/10/03)
A series of bridged monocyclic β-lactams activated by various groups on the β-lactam nitrogen (X = OCH2CO2H, OSO3H) has been synthesized and evaluated. Among them, the bridged sulfactams (X = OSO3H) were found t
A short synthesis of an important precursor to a new class of bicyclic β-lactamase inhibitors
Bellettini, John R.,Miller, Marvin J.
, p. 167 - 168 (2007/10/03)
A short synthesis of an important precursor to known bicyclic β-lactamase inhibitors is described. The synthesis uses commercially available trans-3-hydroxy-L-proline 1. Protection of the amino group followed by formation of the hydroxamate and cyclization using Mitsunobu conditions afforded bicyclic β-lactam 4 in three steps in 53% overall yield.
