187083-45-0

Upstream product

• 187083-38-1 (2-Azido-4,5-dimethoxy-phenyl)-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-methanone 
• 752214-34-9 (S)-1-(2-Azido-4,5-dimethoxy-benzoyl)-pyrrolidine-2-carboxylic acid methyl ester 
• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 
• 147-85-3 L-proline 
• 117573-59-8 2-azido-4,5-dimethoxybenzoic acid 

Relevant academic research and scientific papers

Microwave enhanced reduction of nitro and azido arenes to N-arylformamides employing Zn-HCOONH4: Synthesis of 4(3H)-quinazolinones and pyrrolo[2,1-c][1,4]benzodiazepines

Microwave mediated reduction of nitro and azido arenes to N-arylformamides using Zn-HCOONH4 is described. In the absence of microwave conditions, this methodology affords amines. This protocol has been extended to the synthesis of pyrrolo[2,1-c][1,4]benzodiazepines and 4(3H)-quinazolinones.

Synthesis of DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepines by employing polymer-supported reagents: Preparation of DC-81

Polymer-supported reagents have been utilized for the generation of combinatorial library of substituted pyrrolo[2,1-c][1,4]benzodiazepine derivatives that provides a clean and efficient preparation and does not require conventional purification techniques like chromatography. This methodology involves intra molecular aza-Wittig reaction and has been extended for the synthesis of the natural product DC-81 in good overall yields.

The Synthesis of Functionalized Pyrrolo-[2,1-c][1,4]-Benzodiazepines

Two concise and high yielding routes to the antitumour antibiotic pyrrolo-[2,1-c][1,4]-benzodiazepine ring system are described. Thus, condensation of prolinol with 2-azidobenzoylchloride gives the tertiary amide (3). Oxidation to the aldehyde (4) followe