187083-45-0

Basic information

• Product Name: 2-Pyrrolidinecarboxaldehyde, 1-(2-azido-4,5-dimethoxybenzoyl)-, (2S)-
• CAS NO: 187083-45-0
• Molecular Formula: C14H16N4O4
• Molecular Weight: 304.305
• Mol File: 187083-45-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Pyrrolidinecarboxaldehyde, 1-(2-azido-4,5-dimethoxybenzoyl)-, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrrolidinecarboxaldehyde, 1-(2-azido-4,5-dimethoxybenzoyl)-, (2S)-(187083-45-0)
• EPA Substance Registry System: 2-Pyrrolidinecarboxaldehyde, 1-(2-azido-4,5-dimethoxybenzoyl)-, (2S)-(187083-45-0)

Safety Data

• Hazardous Substances Data: 187083-45-0(Hazardous Substances Data)

Upstream product

• 117573-59-8 2-azido-4,5-dimethoxybenzoic acid 
• 147-85-3 L-proline 
• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 
• 752214-34-9 (S)-1-(2-Azido-4,5-dimethoxy-benzoyl)-pyrrolidine-2-carboxylic acid methyl ester 
• 187083-38-1 (2-Azido-4,5-dimethoxy-phenyl)-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-methanone 

Relevant articles and documents

Microwave enhanced reduction of nitro and azido arenes to N-arylformamides employing Zn-HCOONH4: Synthesis of 4(3H)-quinazolinones and pyrrolo[2,1-c][1,4]benzodiazepines

Microwave mediated reduction of nitro and azido arenes to N-arylformamides using Zn-HCOONH4 is described. In the absence of microwave conditions, this methodology affords amines. This protocol has been extended to the synthesis of pyrrolo[2,1-c][1,4]benzodiazepines and 4(3H)-quinazolinones.

The Synthesis of Functionalized Pyrrolo-[2,1-c][1,4]-Benzodiazepines

Two concise and high yielding routes to the antitumour antibiotic pyrrolo-[2,1-c][1,4]-benzodiazepine ring system are described. Thus, condensation of prolinol with 2-azidobenzoylchloride gives the tertiary amide (3). Oxidation to the aldehyde (4) followe