18714-37-9

Upstream product

• 1076-38-6 4-hydroxy[1]benzopyran-2-one 
• 882-33-7 diphenyldisulfane 
• 2650-14-8 3-bromo-4-hydroxycoumarin 
• 108-98-5 thiophenol 
• 108-95-2 phenol 
• 80-17-1 benzenesufonyl hydrazide 
• 1212-08-4 S-Phenyl benzenethiosulfonate 
• 591-50-4 iodobenzene 
• 98-09-9 benzenesulfonyl chloride 
• 4551-15-9 phenylthiotrimethylsilane 

Downstream Products

• 100954-23-2 4-hydroxy-3-phenylsulfonyl-coumarin 

Relevant academic research and scientific papers

Microwave-Assisted Synthesis and Antimicrobial Activity of 3-(Arylsulfanyl)-4-hydroxy-2H-chromen-2-ones

An efficient microwave-assisted synthesis of 3-(arylsulfanyl)-4-hydroxy-2H-chromen-2-ones by condensation of arenesulfonohydrazides with 4-hydroxy-2H-chromen-2-one in the presence of iodine is described. The synthesized compounds were characterized by spe

Synergistic Dual Role of [hmim]Br-ArSO2Cl in Cascade Sulfenylation-Halogenation of Indole: Mechanistic Insight into Regioselective C-S and C-S/C-X (X = Cl and Br) Bond Formation in One Pot

Bifunctionalized indoles are an important class of biologically active heterocyclic compounds and potential drug candidates. Because of the lack of efficient synthetic methods, one pot cascade synthesis of these compounds is rare and remains a challenge.

HBr/H2O2-mediated formation of C–S bond with thiosulfates

A novel, efficient, and green protocol to construct C–S bond has been developed via HBr/H2O2-mediated sulfenylation of styrenes and 4-hydroxycoumarins leading to unsymmetrical sulfides. Various unsymmetrical sulfides were prepared in one step with moderate to good yields using environmentally-friendly H2O2 as oxidant and HBr as catalyst. Based on the preliminary experimental results, a plausible reaction mechanism was proposed for HBr/H2O2-mediated formation of C–S bond with thiosulfates.

Iodine-mediated sulfenylation of 4-hydroxycoumarins with sulfonyl hydrazides under aqueous conditions

An efficient, metal-free approach to the synthesis of sulfenylated coumarins based on the iodine catalyzed regioselective sulfenylation of 4-hydroxycoumarins with arylsulfonyl hydrazides was developed under mild conditions in water. Various sulfenylated c

3-thioaryl-4-hydroxycoumarin derivative and synthesis method thereof

The invention relates to a preparation method of a 3-thioaryl-4-hydroxycoumarin derivative, and belongs to the field of organic synthesis. The preparation method comprises the following steps: with a4-hydroxycoumarin derivative, sulfur powder and an iodobenzene derivative as raw materials, adding a ligand, an alkali source and a catalyst, and reacting in a solvent to obtain the 3-thioaryl-4-hydroxycoumarin derivative. A sulfur source used in the synthesis is cheap, easy to obtain, stable in performance and environment-friendly; the synthesis method is low in cost, high in reaction yield, mildin condition and easy to operate, and is suitable for industrial production. The derivative has potential application in the field of materials and medicines; by the preparation method, a novel way is provided for the synthesis of the 3-thioaryl-4hydroxycoumarin derivative.

Novel Method for Preparing 4-hydroxy-3-sulfanylcoumarin Derivatives or 4-hydroxy-3-sulfanylquinoline Derivatives and Their Compounds Made Thereby, and Its Use

The present invention relates to 4-hydroxy-3-sulfanylcoumarin derivatives represented by chemical formula 1, 4-hydroxy-3-sulfanylquinolinone derivatives represented by chemical formula 2, novel preparation methods thereof, and uses thereof. According to the present invention, the preparation methods can reduce the preparation cost by utilizing inexpensive catalysts, and at the same time, can yield desired products with high yield. In the chemical formula 1, R_1 to R_4 are as described in the present invention. In the chemical formula 2, R_5 to R_7 are as described in the present invention.COPYRIGHT KIPO 2018

Ammonium Iodide-Mediated Sulfenylation of 4-Hydroxycoumarins or 4-Hydroxyquinolinones with a Sulfonyl Chloride as a Sulfur Source

A novel ammonium iodide-induced sulfenylation of 4-hydroxycoumarins or 4-hydroxyquinolinones by using an aryl- or alkylsulfonyl chloride as the sulfur source gave a wide range of 3-sulfanyl-4-hydroxycoumarins or 3-sulfanyl-4-hydroxyquinolinones, respectiv

Convenient Michael addition/β-elimination approach to the synthesis of 4-benzyl- and 4-aryl-selenyl coumarins using diselenides as selenium sources

A concise and efficient, two-step approach toward 4-organoselenyl coumarin derivatives from the easily available 4-hydroxycoumarins, is reported. The synthesis was based on conventional tosylation followed by a tandem selena-Michael addition/β-elimination reaction of an aryl-/benzyl-selenolate anion on the corresponding 4-tosyloxycoumarins. The selenolate anions were conveniently generated in situ by exposure of the corresponding diselenides to NaBH4. Selected compounds demonstrated to exhibit antioxidant properties in mice cortex and hippocampus.

Copper(I) Bromide-Dimethyl Sulfide-Catalyzed Direct Sulfanylation of 4-Hydroxycoumarins and 4-Hydroxyquinolinones with Arylsulfonylhydrazides and Selective Fluorescence Switch- On Sensing of Cadmium(II) Ion in Water

An efficient protocol for the direct sulfanylation of various 4-hydroxycoumarins and 4-hydroxyquinolinones in good yield with arylsulfonylhydrazides as sulfanylating agents was developed via copper(I) bromide?dimethyl sulfide-catalyzed S–O, S–N bond cleavage and C–S cross-coupling reactions. A highly selective fluorescence turning-on sensing of cadmium(II) ions in water using the synthesized 3-sulfanyl-4-hydroxycoumarin derivative was also investigated. (Figure presented.).

Cooperative catalysis by bovine serum albumin-iodine towards cascade oxidative coupling-C(sp2)-H sulfenylation of indoles/hydroxyaryls with thiophenols on water

Cooperative cascade catalysis by bovine serum albumin (BSA)-iodine allows for the first time the performance of C(sp2)-H sulfenylation of indole from readily available thiophenol (-SH bond) via in situ generation/cleavage of disulfide (S-S bond