187141-99-7

Basic information

• Product Name: [2,3-Dichloro-4-(5-cyano-3-ethyl-6-methoxy-pyridin-2-yl)-phenoxy]-acetic acid
• CAS NO: 187141-99-7
• Molecular Weight: 381.215
• Mol File: 187141-99-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [2,3-Dichloro-4-(5-cyano-3-ethyl-6-methoxy-pyridin-2-yl)-phenoxy]-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [2,3-Dichloro-4-(5-cyano-3-ethyl-6-methoxy-pyridin-2-yl)-phenoxy]-acetic acid(187141-99-7)
• EPA Substance Registry System: [2,3-Dichloro-4-(5-cyano-3-ethyl-6-methoxy-pyridin-2-yl)-phenoxy]-acetic acid(187141-99-7)

Safety Data

• Hazardous Substances Data: 187141-99-7(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 58-54-8 ethacrynic acid 
• 109-77-3 malononitrile 

Relevant articles and documents

Pyridines and pyrimidines from etacrynic acid

The alkoxy-3-cyano-pyridines 2 are obtained from the alcoholate catalyzed reaction of etacrynic acid (1) with malononitrile. Variation of the acidic hydrolysis of 2 yields the acid derivatives 3-5. Ethyl benzoylacetate reacts with 1 and sodium hydroxide to give the 1,5-diketone 6, which cyclizes with ammonium acetate to form the pyridine 7. The ethyl pyridine-3-carboxylate 8 is received from a one pot reaction. The compounds 9 are formed by Michael addition of the barbituric acids to 1. Melting of 9b with ammonium acetate yields the annulated pyridopyrimidine 10. The pyrimidinethione 11 results from the reaction of 1 with thiourea.