187170-61-2Relevant academic research and scientific papers
Total chemical synthesis of human proinsulin
Luisier, Samuel,Avital-Shmilovici, Michal,Weiss, Michael A.,Kent, Stephen B. H.
, p. 8177 - 8179 (2010)
A convergent synthetic strategy based on modern chemical ligation methods was used to make human proinsulin. The synthetic protein was characterized by LCMS, CD spectroscopy, and by 1D- and 2D-NMR spectroscopy. Synthetic human proinsulin had full biochemical activity in a receptor-binding assay.
