187218-01-5Relevant academic research and scientific papers
Design, synthesis, and evaluation of tetrahydroquinoline and pyrrolidine sulfonamide carbamates as γ-secretase inhibitors
Guo, Tao,Gu, Huizhong,Hobbs, Doug W.,Rokosz, Laura L.,Stauffer, Tara M.,Jacob, Biji,Clader, John W.
, p. 3010 - 3013 (2007)
γ-Secretase is a key enzyme involved in the production of β-amyloid peptides which are believed to play a critical role in the onset and progression of Alzheimer's disease (AD). As such, inhibition of γ-secretase has been an attractive approach to AD ther
