158706-46-8

Usage

Chemical Properties

Off-white solid

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 1552271-23-4 (2S,5S)-1-tert-butyl 2-methyl 5-phenylpyrrolidine-1,2-dicarboxylate 
• 195964-54-6 1-tert-butyl 2-methyl (2S)-5-methoxypyrrolidine-1,2-dicarboxylate 
• 188200-05-7 1-(tertbutyloxycarbonyl)-5-(hydroxy)pyrrolidine-2-carboxylic acid methyl ester 
• 108963-96-8 (S)-1-tert-butoxycarbonyl-5-methoxycarbonyl-pyrrolidin-2-one 
• 4931-66-2 methyl (S)-pyroglutamate 
• 98-79-3 L-Pyroglutamic acid 
• 663956-49-8 (2RS,5R)-2-cyano-5-phenylpyrrolidine-1-carboxylic acid t-butyl ester 
• 100-58-3 phenylmagnesium bromide 
• 861657-91-2 rac-1-(tert-butyl) 2-methyl 5-oxopyrrolidine-1,2-dicarboxylate 

Downstream Products

• 1601476-00-9 C₁₆H₂₁NO₃ 
• 1601475-96-0 (2S,5R)-1-benzyl-2-hydroxymethyl-5-phenylpyrrolidine 
• 1601475-98-2 C₁₈H₂₁NO 
• 1601475-80-2 C₃₉H₃₈F₆N₄O₅ 
• 1009093-78-0 C₄₇H₆₅N₅O₆ 

Relevant academic research and scientific papers

COMPOUNDS AND USES THEREOF

The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

A Catalyst Designed for the Enantioselective Construction of Methyl- and Alkyl-Substituted Tertiary Stereocenters

Tertiary methyl-substituted stereocenters are present in numerous biologically active natural products. Reported herein is a catalytic enantioselective method for accessing these chiral building blocks using the Mukaiyama-Michael reaction between silyl ketene thioacetals and acrolein. To enable remote enantioface control on the nucleophile, a new iminium catalyst, optimized by three-parameter tuning and by identifying substituent effects on enantioselectivity, was designed. The catalytic process allows rapid access to chiral thioesters, amides, aldehydes, and ketones bearing an α-methyl stereocenter with excellent enantioselectivities, and allowed rapid access to the C4-C13 segment of (-)-bistramide A. DFT calculations rationalized the observed sense and level of enantioselectivity.

Flexible and modular syntheses of enantiopure 5-cis-substituted prolinamines from l-pyroglutamic acid

A wide range (25 examples) of 5-cis-substituted prolinamines is prepared in five to ten steps starting from cheap l-pyroglutamic acid. Three routes, differing mainly in the order of introduction of the substituents at the 5-cis position, the pyrrolidine nitrogen atom, and the exocyclic amino function, are successfully developed.

NITROGEN-CONTAINING COMPOUNDS

A compound represented by formula (I); wherein ring A represents a nitrogen containing heterocyclic ring, ring B represents 5-membered heterocyclic ring which may have substituents, R represents a hydrogen atom or cyano and the other symbols represent as

VLA-4 inhibitor compounds

Compounds that selectively inhibit the binding of ligands to alpha4beta1 integrin (VLA-4) and methods for their preparation are disclosed. In one embodiment, compounds of the invention are represented by Formula I: As selective inhibitors of VLA-4 mediated cell adhesion, compounds of the present invention are useful in the treatment of conditions associated with such adhesion, including, but not limited to, such conditions as inflammatory and autoimmune responses, diabetes, asthma, psoriasis, inflammatory bowel disease, transplantation rejection, and tumor metastasis. Also disclosed are pharmaceutical compositions, methods of inhibiting VLA-4 mediated cell adhesion and methods of treating conditions associated with LA-4 mediated cell adhesion, which involve compounds of Formula I.