187237-37-2

Usage

Uses

Used in Organic Synthesis:
TERT-BUTYL [(5-(AMINOMETHYL)PYRIDIN-2-YL]CARBAMATE is used as a reagent in chemical reactions and synthesis for its ability to serve as a protective group for amines. This function is crucial in organic synthesis to prevent unwanted reactions from occurring at the amine group.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, TERT-BUTYL [(5-(AMINOMETHYL)PYRIDIN-2-YL]CARBAMATE is used as an intermediate for the production of various compounds with biological activity. Its unique structure allows for the creation of new pharmaceuticals with potential therapeutic applications.
Used in Agrochemical Synthesis:
Similarly, in the agrochemical industry, TERT-BUTYL [(5-(AMINOMETHYL)PYRIDIN-2-YL]CARBAMATE is utilized as an intermediate in the synthesis of compounds that have applications in agriculture, such as pesticides and herbicides, due to its potential to contribute to the development of effective and targeted agrochemicals.
Used in the Production of Chemical Products:
TERT-BUTYL [(5-(AMINOMETHYL)PYRIDIN-2-YL]CARBAMATE is a key component in the manufacturing process of a wide array of chemical products, highlighting its versatility and importance in the chemical industry. Its role as an intermediate allows for the development of new products with diverse applications.

InChI:InChI=1/C11H17N3O2/c1-11(2,3)16-10(15)14-9-5-4-8(6-12)7-13-9/h4-5,7H,6,12H2,1-3H3,(H,13,14,15)

Upstream product

• 902837-44-9 tert-butyl (5-cyanopyridin-2-yl)carbamate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 4214-73-7 6-aminonicotinonitrile 
• 874-42-0 2,4-dichlorobenzaldeyhde 

Downstream Products

• 1038387-99-3 C₁₈H₂₁N₃O₃ 
• 1161013-91-7 [5-(3-{4-[6-Ethylamino-5-(2-(piperidin-1-yl)ethylcarbamoyl)pyridin-2-yl]phenyl}-ureidomethyl)pyridin-2-yl]carbamic acid tert-butyl ester 
• 1363155-26-3 tert-butyl 5-((3-(4-(phenylsulfonyl)phenyl)ureido)methyl)pyridin-2-ylcarbamate 
• 1363150-15-5 tert-butyl N-{5-[({[4-(piperidine-1-sulfonyl)phenyl]carbamoyl}amino)methyl]pyridin-2-yl}carbamate 
• 1363152-08-2 1-(6-aminopyridin-3-ylmethyl)-3-(4-(piperidine-1-yl)sulfonyl)urea 
• 156973-09-0 2-amino-5-aminomethyl-pyridine 

Relevant academic research and scientific papers

SUBSTITUTED BENZAMIDES AS MODULATORS OF TREX1

Provided are compounds of Formula (I): (I) and pharmaceutically acceptable salts and compositions thereof, which are useful for treating a variety of conditions associated with TREX1.

Small Molecule Inhibitors Simultaneously Targeting Cancer Metabolism and Epigenetics: Discovery of Novel Nicotinamide Phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) Dual Inhibitors

Cancer metabolism and epigenetics are among the most intensely pursued research areas in anticancer drug discovery. Here we report the first small molecules that simultaneously inhibit nicotinamide phosphoribosyltransferase (NAMPT) and histone deacetylase (HDAC), two important targets of cancer metabolism and epigenetics, respectively. Through iterative structure-based drug design, chemical synthesis, and biological assays, a highly potent dual NAMPT and HDAC inhibitor was successfully identified. Compound 35 possessed excellent and balanced activities against both NAMPT (IC50 = 31 nM) and HDAC1 (IC50 = 55 nM). It could effectively induce cell apoptosis and autophagy and ultimately led to cell death. Importantly, compound 35 showed excellent in vivo antitumor efficacy in the HCT116 xenograft model. This proof-of-concept study demonstrates the feasibility of discovering an inhibitor targeting cancer metabolism and epigenetics and provides an efficient strategy for multitarget antitumor drug discovery.

THERAPEUTIC INHIBITORY COMPOUNDS

The invention provides compounds of Formula I and Formula II: A-B-C-D-E-F-G-J (I) C-D-E-F-G-J (II) wherein A, B, C, D, E, F, G, and J have any of the values defined in the specification, and salts thereof. The compounds are useful for inhibiting plasma kallikrein, and for treating a disease or condition in an animal where inhibition of plasma kallikrein is indicated.

From selective substrate analogue factor Xa inhibitors to dual inhibitors of thrombin and factor Xa. Part 3

Highly potent and selective substrate analogue factor Xa inhibitors were obtained by incorporation of non-basic or modestly basic P1 residues known from the development of thrombin inhibitors. The modification of the P2 and P3 amino acids strongly influenced the selectivity and provided potent dual factor Xa and thrombin inhibitors without affecting the fibrinolytic enzymes. Several inhibitors demonstrated excellent anticoagulant efficacy in standard clotting assays in human plasma.