187239-87-8

Upstream product

• 116546-78-2 (S)-1-benzyloxy-2-methylpentan-3-one 
• 78-84-2 isobutyraldehyde 

Downstream Products

• 187239-88-9 Benzoic acid (1S,2R,3S,4S)-5-benzyloxy-3-hydroxy-1-isopropyl-2,4-dimethyl-pentyl ester 
• 187239-90-3 Benzoic acid (E)-(1S,2S,3S,4S)-6-iodo-1-isopropyl-2,4-dimethyl-3-triethylsilanyloxy-hex-5-enyl ester 
• 187239-89-0 Benzoic acid (1S,2S,3R,4R)-1-isopropyl-2,4-dimethyl-5-oxo-3-triethylsilanyloxy-pentyl ester 
• 187239-91-4 Benzoic acid (E)-(1S,2R,3S,4S)-3-hydroxy-6-iodo-1-isopropyl-2,4-dimethyl-hex-5-enyl ester 

Relevant academic research and scientific papers

Studies in macrolide synthesis: A novel cyclodimerisation approach to the synthesis of elaiophylin using a double stille cross-coupling reaction

The 16-membered macrodiolide 4, corresponding to the macrocyclic core of elaiophylin (1), was prepared via the copper-mediated cyclodimerisation of stannane 3.

The Total Synthesis of Swinholide A. Part 3: A Stereocontrolled Synthesis of (-)-Pre-Swinholide A.

Two coupling strategies for (-)-pre-swinholide A were devised based on the analysis in Scheme 1.In the first route, a boron-mediated aldol reaction between the ethyl ketone 19 and the aldehyde 3 was used to construct the C15-C16 bond with moderate diaster