187242-93-9

Basic information

• Product Name: 2-Pyridinecarbonitrile,3-amino-6-methyl-(9CI)
• Synonyms: 2-Pyridinecarbonitrile,3-amino-6-methyl-(9CI);3-aMino-6-Methylpicolinonitrile
• CAS NO: 187242-93-9
• Molecular Formula: C7H7N3
• Molecular Weight: 133.15058
• Product Categories: PYRIDINE
• Mol File: 187242-93-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 2-Pyridinecarbonitrile,3-amino-6-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinecarbonitrile,3-amino-6-methyl-(9CI)(187242-93-9)
• EPA Substance Registry System: 2-Pyridinecarbonitrile,3-amino-6-methyl-(9CI)(187242-93-9)

Safety Data

• Hazardous Substances Data: 187242-93-9(Hazardous Substances Data)

Upstream product

• 126325-53-9 3-amino-2-bromo-6-methylpyridine 
• 187242-96-2 2-Cyano-6-methyl-nicotinic acid ethyl ester 
• 187242-97-3 2-Cyano-6-methyl-nicotinic acid 
• 21901-29-1 6-amino-5-nitro-2-picoline 
• 56057-19-3 2-chloro-6-methyl-3-nitropyridine 
• 39073-14-8 ethyl 2-chloro-6-methyl-3-pyridinecarboxylate 
• 70959-85-2 ethyl 2-amino-6-methylnicotinate 
• 187242-90-6 6-methyl-3-nitro-pyridine-2-carbonitrile 

Relevant articles and documents

4-ARYLQUINAZOLINE DERIVATIVES AS INHIBITORS OF METHIONINE ADENOSYLTRANSFERASE 2A

The invention relates to certain derivatives of 4-arylquinazoline formula (I) which are inhibitors of methionine adenosyltransferase 2A (MAT2A). The invention also relates to pharmaceutical compositions comprising such compounds and methods of treating diseases that can be treated by inhibition of MAT2A such as cancer, including cancers characterized by reduced or no activity of methylthioadenosine phosphorylase (MTAP).

Versatile synthesis of 6-substituted 8-deazapteridine-2,4-diamines. Formal total synthesis of 8,10-dideazaminopterin

A new synthesis of 4-amino-4-deoxy-8,10-dideazapteroic acid (11d) and 6-substituted and 5,6-anellated 8-deazapteridine-2,4-diamines, 10a, 10d, 25, is described. Starting from keteneaminals 1 or 12 and enaminones 4 or β-aminoketone 17 the title compounds can be prepared via functional group transformation of 2-amino-3-nitropyridines 5 or nicotinate 13a yielding 3-amino-α-picolinonitriles 9 which are cyclocondensed with guanidine.