39073-14-8

Usage

InChI:InChI=1/C9H10ClNO2/c1-3-13-9(12)7-5-4-6(2)11-8(7)10/h4-5H,3H2,1-2H3

Upstream product

• 51146-04-4 ethyl 2-hydroxy-6-methylpyridine-3-carboxylate 
• 70959-85-2 ethyl 2-amino-6-methylnicotinate 
• 30529-70-5 2-chloro-6-methyl nicotinic acid 
• 13103-07-6 ethyl 2,2-dichlorocyanoacetate 
• 78-94-4 methyl vinyl ketone 
• 105-56-6 ethyl 2-cyanoacetate 
• 64-17-5 ethanol 
• 38116-61-9 2-hydroxy-6-methylnicotinic acid 
• 68572-18-9 ethyl 3,3-diaminoacrylate 

Downstream Products

• 143618-37-5 2-{Butyl-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-6-methyl-nicotinic acid ethyl ester 
• 1097221-02-7 3,6-dimethyl-1-(4-methylphenyl)-1H-pyrrolo[2,3-b]pyridine 
• 1097221-03-8 3-ethyl-2,6-dimethyl-1-(4-methylphenyl)-1H-pyrrolo[2,3-b]pyridine 
• 1097220-78-4 2-[6-methyl-2-(4-methylphenylamino)pyridin-3-yl]propan-2-ol 
• 1097220-79-5 3-[6-methyl-2-(4-methylphenylamino)pyridin-3-yl]pentan-3-ol 
• 883241-16-5 6-methyl-2-(4-trifluoromethylphenyl)nicotinic acid 
• 65239-36-3 2-(4-chloro-phenoxy)-6-methyl-nicotinic acid 
• 1239354-67-6 2-[(4-chlorophenyl)oxy]-6-methyl-N-[(1R)-2-(4-methylpiperazin-1-yl)-2-oxo-1-{[(phenylmethyl)oxy]methyl}ethyl]pyridine-3-carboxamide 
• 141871-69-4 2-{Butyl-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-6-methyl-nicotinic acid ethyl ester 
• 141871-70-7 2-{Butyl-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-6-methyl-nicotinic acid 
• 187242-93-9 3-amino-6-methyl-pyridine-2-carbonitrile 

Relevant academic research and scientific papers

With insecticidal or acaricidal activity of the 2 - phenyl nicotinic acid derivatives (by machine translation)

The invention belongs to the field of agricultural insecticidal agents. In particular relates to a with insecticidal or acaricidal activity of the 2 - phenyl nicotinic acid derivatives. Compound such as shown in formula I: in the formula of each substitue

HETEROCYCLIC AMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS

The invention relates to heterocyclic amide derivatives of formula (I), wherein R1, R2, R3, R4, R5, X, Y and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.

HETEROCYCLIC AMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS

The invention relates to heterocyclic amide derivatives of formula (I), wherein R1, R2, R3, R4, R5, X, Y and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.

2-PHENYLNICOTINIC ACID DERIVATIVE

The present invention is to provide the compounds useful as a treating or preventing agent for gout and hyperuricemia which are 2-phenylnicotinic acid derivatives having a uric acid lowering action due to an excellent xanthine oxidase inhibitory action. Since the 2-phenylnicotinic acid derivatives of the present invention exhibit a uric acid lowering action due to an excellent xanthine oxidase inhibitory action and also hypolipemic action, their utility is very high as a treating or preventive agent for gout and hyperuricemia which are often accompanied by hyperlipemia as a complication.

Isoxazole derivatives

An isoxazole compound having the following formula: wherein R1 represents hydrogen, halogen, alkyl, alkoxy, hydroxyl, alkylthio, amino, alkanoyl, alkanoylamino, alkanoyloxy, alkoxycarbonyl, carboxy, (alkylthio)thiocarbonyl, carbamoyl, nitro or cyano; R2 represents an amino; m is 1; n is 1 to 6; ring A represents a phenyl ring or a naphthyl ring; and X represents oxygen or sulfur. The isoxazole compound has an excellent monoamine oxidase inhibitory activity, and is useful for treating Parkinson's disease, depression and Alzheimer's disease.

Versatile synthesis of 6-substituted 8-deazapteridine-2,4-diamines. Formal total synthesis of 8,10-dideazaminopterin

A new synthesis of 4-amino-4-deoxy-8,10-dideazapteroic acid (11d) and 6-substituted and 5,6-anellated 8-deazapteridine-2,4-diamines, 10a, 10d, 25, is described. Starting from keteneaminals 1 or 12 and enaminones 4 or β-aminoketone 17 the title compounds can be prepared via functional group transformation of 2-amino-3-nitropyridines 5 or nicotinate 13a yielding 3-amino-α-picolinonitriles 9 which are cyclocondensed with guanidine.

Processes for producing 2-Halo-nicotinic acid derivatives and precursors thereto

Disclosed are preferred processes for the preparation of 2-halo-nicotinic acid derivatives of formula (IV): STR1 by cyclocondensation of a 4-halo-4-cyanocarbonyl compound of formula (III): STR2 wherein X is Cl or Br; Y is a carbonyl group and R1, R2 and R3 are each, independently, H, Cl, Br or an organic radical. Further preferred aspects include the preparation of the above-noted 4-halo-4-cyanocarbonyl compound via Michael addition of a 2-halonitrile with an α,β-unsaturated aldehyde or ketone, and the preparation of the 2-halonitrile by redistribution of halogen between a 2,2-dihalonitrile and a parent nitrile.

Regioselective synthesis of 2-chloro 3-pyridinecarboxylates

2-Chlorocyanoacetate was found to undergo base-catalyzed Michael addition to α,β-unsaturated ketones or aldehydes to afford 5-oxopentenenitrile derivatives. In the presence of anhydrous HCl, these compounds cyclize to yield 2-chloro-3-pyridinecarboxylates. The process is highly regiospecific and useful in the synthesis of 2,3-disubstituted pyridines.

GENERAL ROUTES TO 4-OXO-4H-PYRANOPYRIDINE-3-CARBOXYLATES AND RELATED COMPOUNDS: SYNTHESIS OF THE OXYGEN AND SULFUR ISOSTERES OF NALIDIXIC ACID

Imidazolides of 2-hydroxy- and 2-mercaptonicotinic acids with LiCH2CO2Bu-t gave ketoesters which were cyclised with MeOCH=NMe2+ MeOSO3- and i-Pr2NEt or with (RCO)2O-NEt3-DMAP to the title 2-H or 2-R bicyclic esters; the corresponding

Angiotensin II receptor antagonists

Compounds are disclosed having the formula: STR1 The compounds of the invention are angiotensin II receptor antagonists.