187266-01-9Relevant academic research and scientific papers
Synthesis of bicyclic homochiral dienes by allylic rearrangement of cyclohexenols - Suitable building blocks for the synthesis of nagilactones
Westermann, Bernhard,Dubberke, Silke
, p. 375 - 380 (1997)
A very short and straightforward synthesis towards highly functionalized dienes is described. The homochiral starting material, unsaturated β-oxo ester 2, can be prepared by enzyme-catalyzed saponification. The utility of the dienes has been demonstrated in a cycloaddition with N-phenyltriazolidinone as the dienophile. The Diels-Alder reaction is highly diastereoselective, yielding only one diastereomer. VCH Verlagsgesellschaft mbH, 1997.
