18732-58-6

Upstream product

• 123-75-1 pyrrolidine 
• 128827-84-9 1-(1,3-Dithiolan-2-yliden)-1-phenyl-2-butanon-S-oxid 
• 98-86-2 acetophenone 
• 3389-53-5 phenylacetylpyrrolidine 
• 932-87-6 1-Bromo-2-phenylacetylene 
• 621-82-9 Cinnamic acid 
• 536-74-3 phenylacetylene 
• 102861-59-6 1-(1,3-Dithiolan-2-yliden)-1-phenyl-2-butanon 
• 151-10-0 1,3-Dimethoxybenzene 

Downstream Products

• 6908-75-4 N-(2-phenylethyl)pyrrolidine 

Relevant academic research and scientific papers

Rapid and efficient protocol for Willgerodt–Kindler’s thioacetamides catalyzed by sulfated polyborate

Abstract: A simple and efficient method for the synthesis of one-pot, three-component thioacetamides via Willgerodt–Kindler reaction was developed using a sulfated polyborate catalyst. The method described the reaction of ketones, sulfur, and secondary am

Three-component reaction between alkynes, elemental sulfur, and aliphatic amines: A general, straightforward, and atom economical approach to thioamides

A general, straightforward, and atom-economical three-component synthesis of thioamides from alkynes, elemental sulfur, and aliphatic amines has been developed.

Decarboxylative thioamidation of arylacetic and cinnamic acids: A new approach to thioamides

A new decarboxylative strategy has been developed for the synthesis of thioamides via a three-component reaction involving arylacetic or cinnamic acids, amines and elemental sulfur powder, without the need of a transition metal and an external oxidant.

Synthesis of thioamides via one-pot A3-coupling of alkynyl bromides, amines, and sodium sulfide

We herein describe a novel method for the synthesis of thioamides by a three component condensation of alkynyl bromides, amines, and Na 2S·9H2O. The developed method is applicable for a wide range of amines and alkynyl bromides bearing different functional groups furnishing the corresponding products in moderate to excellent yields. The Royal Society of Chemistry.

Ultrasound-mediated willgerodt-kindler reactions: Non-thermal synthesis of thioacetamides

Non-thermal, solvent-free condensation of several aryl methyl ketones with amines and elemental sulfur is efficiently conducted using ultrasonic irradiation within short time periods. Consequently, various thioacetamides are conveniently synthesized. Simi

Thionation of amides using a solid-supported P2S5 reagent under microwave irradiation

In this Letter, we describe an improved method for the thionation of amides. Using a solid-supported P2S5 reagent, heating under microwave irradiation furnished thioamides in good to excellent yields, with a significantly reduced reaction time compared with that achieved under conventional heating. Furthermore, a change of solvent from that described in the literature enabled a simplified work-up and purification of the products.

Thioketene Syntheses, VIII. - Thioketenes by Cycloreversion of 1,3-Dithiolane Derivatives

2-Alkylidene-1,3-dithiolanes are transformed into S,S-dioxides 1 and S-ethyl- 2 or S-arylsulfonium salts 3.After deprotonation at C-5 they form in a cycloreversion thioketenes 5, which can be trapped as thioamides 17, 18.The stabilized thioketenes 5e,i-k afford 1:1 cycloadducts 24a, b, 27a-d with azomethines; in addition, thioketene 5j provides a dimer 28j, which was characterized by an X-ray structural investigation.

Optimum Conditions for the Willgerodt-Kindler Reaction. 3. Amine Variation

Optimum conditions for the synthesis of phenylacetic acid thioamids by the joint action of elemental sulfur and amines on acetophenons have been studied with the following amines: Morpholine, pyrrolidine, 4-methylpiperidine, isopropylamine, 2-butylamine,

GENERATION OF THIOKETENES VIA CYCLOREVERSION OF 1,3-DITHIOLANE-DERIVED SULFUR YLIDES

On treatment with base, 1-aryl-2-alkylidene-1,3-dithiolanium salts 6 give clean cycloreversion providing thioketenes 3 and vinyl sulfides 7.