187396-92-5

Upstream product

• 33245-78-2 5-chloro-1-(2,4-dimethoxyphenyl)pentan-1-one 
• 151-10-0 1,3-Dimethoxybenzene 
• 1575-61-7 5-Chlorovaleroyl chloride 

Downstream Products

• 187396-97-0 5-chloro-1-(5-amino-2,4-dimethoxyphenyl)-1-pentanone 
• 187397-01-9 N-[5-(5-Chloro-pentanoyl)-2,4-dimethoxy-phenyl]-4-methyl-benzenesulfonamide 
• 187397-00-8 N-[5-(5-chloropentanoyl)-2,4-dimethoxyphenyl]-4-trifluoromethylbenzenesulfonamide 
• 185376-97-0 N-{5-[5-(2,4-dioxo-1,3,8-triazaspiro[4.5]dec-8-yl)pentanoyl]-2,4-dimethoxyphenyl}-4-trifluoromethylbenzenesulfonamide 

Relevant academic research and scientific papers

1,3,8-TRIAZA- AND 3,8-DIAZA-1-OXASPIRO[4,5] DECANE DERIVATIVES

Heterocyclic compounds of Formula I: STR1 in which n is 2, 3, 4, 5 or 6; t is 1, 2, 3 or 4; u is 0 or 1 (provided that t is not 1 when u is 0); X is O or N(R 4); Y and Z are independently C(O), C(S) or CH 2 (provided that Y and Z are not both CH 2); R 1, R. sup.2, R 3, and R 4 are as defined in the specification; and their pharmaceutically acceptable salts and N-oxides, formulations containing them, their uses as therapeutic agents, and their synthesis.

Some benzenesulfonamido-substituted valerophenones that are selective antagonists for the 5-HT(2C) receptor

Substituted benzenesulfonyl derivatives of m-aminovalerophenones bearing a 1,3,8-triazaspiro[4.5]decane-2,4-dione at the alkyl terminus are the first known, selective ligands for the 5-HT(2C) receptor. A brief structure-activity relationship of this series is outlined.