185376-97-0 Usage
Uses
RS 102221 Hydrochloride is a selective 5-HT2C receptor antagonist.
Biological Activity
Potent and selective 5-HT 2C antagonist (pK i = 8.7). Displays ~ 100-fold selectivity over the 5-HT 2A and 5-HT 2B subtypes and is > 100-fold selective over other 5-HT receptors, a- and b-adrenergic and muscarinic ACh receptors.
Check Digit Verification of cas no
The CAS Registry Mumber 185376-97-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,5,3,7 and 6 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 185376-97:
(8*1)+(7*8)+(6*5)+(5*3)+(4*7)+(3*6)+(2*9)+(1*7)=180
180 % 10 = 0
So 185376-97-0 is a valid CAS Registry Number.
InChI:InChI=1/C27H31F3N4O7S.ClH/c1-40-22-16-23(41-2)20(33-42(38,39)18-8-6-17(7-9-18)27(28,29)30)15-19(22)21(35)5-3-4-12-34-13-10-26(11-14-34)24(36)31-25(37)32-26;/h6-9,15-16,33H,3-5,10-14H2,1-2H3,(H2,31,32,36,37);1H
185376-97-0Relevant academic research and scientific papers
Weinhardt, Klaus K.,Bonhaus, Douglas W.,De Souza, Andrea
, p. 2687 - 2692 (1996)
Substituted benzenesulfonyl derivatives of m-aminovalerophenones bearing a 1,3,8-triazaspiro[4.5]decane-2,4-dione at the alkyl terminus are the first known, selective ligands for the 5-HT(2C) receptor. A brief structure-activity relationship of this series is outlined.
