Bioorganic and Medicinal Chemistry Letters p. 309 - 314 (1997)
Update date:2022-07-29
Topics:
Madden, Brenda A.
Prestwich, Glenn D.
Truncated, 22(23)-dihydro, and fluorinated analogues of (3S)-29-methylidene-2,3-oxidosqualene (29-MOS) were prepared and inhibitory potencies and rates of inactivation of rat oxidosqualene cyclase were measured. Rapid mechanism-based enzyme inactivation was observed for both methylidene and difluoromethylidene analogues with complete pro-side chains, but not for truncated analogues.
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