187402-06-8Relevant academic research and scientific papers
Development of tools for the design of selectin antagonists
Kolb, Hartmuth C.,Ernst, Beat
, p. 1571 - 1578 (1997)
A molecular modeling tool for the rational design of E-selectin antagonists based on the lead structure sialyl Lewis(x) has been developed. The binding affinity to the receptor is considerably influenced by the entropy and consequently by the antagonist's
