Development of tools for the design of selectin antagonists

DOI: 10.1002/chem.19970031006

Source and publish data:

Chemistry - A European Journal p. 1571 - 1578 (1997)

Update date:2022-08-02

Topics:

Authors:

Kolb, Hartmuth C.

Ernst, Beat

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Article abstract of DOI:10.1002/chem.19970031006

A molecular modeling tool for the rational design of E-selectin antagonists based on the lead structure sialyl Lewis(x) has been developed. The binding affinity to the receptor is considerably influenced by the entropy and consequently by the antagonist's

Full text of DOI:10.1002/chem.19970031006

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