187409-93-4

Basic information

• Product Name: 1-(5-hydroxy-3-methyl-pent-3-en-1-ynyl)-2,2,6-trimethyl-cyclohexanol
• Synonyms: 1-(5-hydroxy-3-methyl-pent-3-en-1-ynyl)-2,2,6-trimethyl-cyclohexanol
• CAS NO: 187409-93-4
• Molecular Weight: 236.354
• Mol File: 187409-93-4.mol

Chemical Properties

• CAS DataBase Reference: 1-(5-hydroxy-3-methyl-pent-3-en-1-ynyl)-2,2,6-trimethyl-cyclohexanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-hydroxy-3-methyl-pent-3-en-1-ynyl)-2,2,6-trimethyl-cyclohexanol(187409-93-4)
• EPA Substance Registry System: 1-(5-hydroxy-3-methyl-pent-3-en-1-ynyl)-2,2,6-trimethyl-cyclohexanol(187409-93-4)

Safety Data

• Hazardous Substances Data: 187409-93-4(Hazardous Substances Data)

Upstream product

• 925-90-6 ethylmagnesium bromide 
• 6153-05-5 (Z)-3-methylpent-2-en-4-ynol 
• 2408-37-9 2,2,6-trimethylcyclohexan-1-one 

Downstream Products

• 187339-51-1 (2Z,4E)-3-methyl-5-(1-hydroxy-2,2,6-trimethylcyclohexyl)-pent-2,4-dien-1-ol 
• 29411-53-8 optically inactive 1-(5-hydroxy-3-methyl-penta-1,3ξ-dien-ξ-yl)-2,2,6-trimethyl-cyclohexanol 
• 855474-14-5 3-methyl-5-(2,6,6-trimethyl-cyclohex-1-enyl)-pent-2-en-4-ynal 
• 137047-34-8 (Z)-3-Methyl-5-(2,6,6-trimethyl-cyclohex-1-enyl)-pent-2-en-4-yn-1-ol 
• 187339-59-9 methyl-(2E,4E,6Z,8E)-3-³H₃C,7-methyl-9-(2,2,6-trimethylcyclohex-1-enyl)-nona-2,4,6,8-tetraenoate 
• 187339-58-8 C₂₁H₂₇⁽²⁾H₃O₂ 
• 187339-55-5 (2E,4Z,6E)-1-³H₃C,5-methyl-7-(2,2,6-trimethylcyclohex-1-enyl)-hepta-2,4,6-triene-1-ol 
• 187339-54-4 C₁₈H₂₅⁽²⁾H₃O 
• 187339-57-7 (2E,4Z,6E)-1-³H₃C,5-methyl-7-(2,2,6-trimethylcyclohex-1-enyl)-hepta-2,4,6-triene-1-one 
• 187339-56-6 C₁₈H₂₃⁽²⁾H₃O 
• 187339-53-3 (2E,4Z,6E)-7-(1-Hydroxy-2,2,6-trimethyl-cyclohexyl)-5-methyl-hepta-2,4,6-trienoic acid methyl ester 
• 78769-76-3 (3E,5Z,7E)-6-Methyl-8-(2,6,6-trimethyl-cyclohex-1-enyl)-octa-3,5,7-trien-2-ol 
• 187339-52-2 (2Z,4E)-3-methyl-5-(1-hydroxy-2,2,6-trimethylcyclohexyl)-pent-2,4-dien-1-al 
• 14398-59-5 (2E,4Z,6E)-5-Methyl-7-(2,6,6-trimethyl-cyclohex-1-enyl)-hepta-2,4,6-trienoic acid methyl ester 

Relevant articles and documents

Synthesis of 9-cis-retinoic acid and C-20-[3H3C]-9-cis-retinoic acid with high specific activity

The synthesis of 9-cis-retinoic acid starting from 2,2,6-trimethylcyclohexanone is described. The same methodology was extended for the synthesis of deuterium and tritium labeled 9-cis-retinoic acid with high specific activity (73 Ci/mmol). In this methodology, a Grignard reaction was utilized for introducing three tritium atoms simultaneously in the final synthetic steps.

Synthesis method of new compounds Potassium all-trans retinoate and Potassium 9-cis retinoate.

A method for synthesizing all-cis retinoate by adding trans retinoic acid after 9 - cis retinoic acid addition to Hexane-KOH and Potassium all, followed by combining trans retinoate to Potassium all and Potastastastastastastastasy, trans retinoate-cis β LogP-9 which measures the absorption rate at a long time when administered orally, which has an effect of lowering the risk of cancer and cardiovascular diseases carotene. The cardiovascular therapeutic agent of 9, wherein the cardiovascular therapeutic agent is administered orally. The present invention relates to a therapeutic agent for atherosclerosis and a therapeutic agent for angina pectoris.

A synthesis method of 9-cis Beta-carotene

The present invention relates to a method for synthesizing 9 - cis Beta-carotene (9 - cis beta-carotene) compounds having high purity and easy mass production through a chemical reaction, and a reaction for substituting 9 - cis Retinol groups of Alcohol with 9 - cis Phosphonium salt. The reaction of β - (3 - Methyl-2-butenal to Knoevenagel condensation) to synthesize All-trans Aldehyde. In step 9 - cis Retinoic Phosphonium salt) and in step), the completed All-trans Aldehyde is subjected to Wittig Olefination reaction with carbon double bonds, and 9. cis Beta-carotene obtained by the reaction of carbon double bonds.