Journal of labelled compounds and radiopharmaceuticals p. 1 - 10 (1997)
Update date:2022-07-30
Topics:
Tadikonda, Praveen K.
Lacy, James M.
Rigdon, Michael G.
Deluca, Hector F.
The synthesis of 9-cis-retinoic acid starting from 2,2,6-trimethylcyclohexanone is described. The same methodology was extended for the synthesis of deuterium and tritium labeled 9-cis-retinoic acid with high specific activity (73 Ci/mmol). In this methodology, a Grignard reaction was utilized for introducing three tritium atoms simultaneously in the final synthetic steps.
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Doi:10.1002/chem.19970030112
(1997)Doi:10.1021/ol402559z
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