187480-40-6

Upstream product

• 620-23-5 m-tolyl aldehyde 
• 109-81-9 N-methyl-ethane-1,2-diamine 
• 195132-53-7 N-(m-methylbenzyl)-2-aminoethanol 
• 187480-23-5 N'-tert-butoxycarbonyl-N'-methyl-N-(3-methylbenzyl)ethylenediamine 
• 74-89-5 methylamine 

Downstream Products

• 129294-09-3 N-[1-(3-methylbenzyl)-4-methylhexahydro-1H-1,4-diazepin-6-yl]-1H-indazole-3-carboxamide 
• 151526-82-8 (R)-N-[1-methyl-4-(3-methyl)benzylhexahydro-1,4-diazepin-6-yl]-1H-indazole-3-carboxamide 
• 151526-83-9 (S)-N-[1-methyl-4-(3-methyl)benzylhexahydro-1,4-diazepin-6-yl]-1H-indazole-3-carboxamide 
• 187480-23-5 N'-tert-butoxycarbonyl-N'-methyl-N-(3-methylbenzyl)ethylenediamine 
• 21149-17-7 methyl 2-(benzyloxycarbonylamino)acrylate 

Relevant academic research and scientific papers

Synthesis and resolution of (±)-N-[1-methyl-4-(3-methylbenzyl)hexahydro-1H-1,4-diazepin-6-yl]-1H-indazole -3-carboxamide by preferential crystallization

(±)-N-[1-Methyl-4-(3-methylbenzyl)hexahydro-1H-1,4-diazepin-6-yl]-1H-indazole -3-carboxamide (±)-1 was prepared from N-methyl-N'-(3-methylbenzyl)ethylenediamine 5 and 2-(1-benzyloxycarbonyl-1H-indazole-3-carbonylamino)propenal 4 and was found to exist as

Efficient synthesis of (6R)-6-amino-1-methyl-4-(3-methylbenzyl)-hexahydro-1H-1,4-diazepine from methyl (2R)- and (2S)-1-benzyloxycarbonylaziridine-2-carboxylates

An efficient and practical method for the synthesis of (6R)-6-amino-1-methyl-4-(3-methylbenzyl)hexahydro-1H-1,4-diazepine 2, which serves as the amine part of DAT-582, a potent and selective 5-HT3 receptor antagonist, is described. The key inte