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18766-66-0

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18766-66-0 Usage

General Description

(2S,4E)-1,2,3,4-Tetrahydro-4-(2-oxoethylidene)pyridine-2,6-dicarboxylic acid, also known as kynurenic acid, is a naturally occurring neuroactive metabolite in the human body. It is derived from the metabolism of the amino acid L-tryptophan and is found in high concentrations in the brain and other tissues. Kynurenic acid acts as an antagonist at the glycine site of the N-methyl-D-aspartate (NMDA) receptor, which plays a crucial role in the regulation of synaptic transmission and plasticity in the central nervous system. It also has been implicated in the regulation of glutamate and dopamine neurotransmission, as well as in the pathophysiology of various neurological and psychiatric disorders. Additionally, kynurenic acid has immunomodulatory and antioxidant properties, making it a potential target for therapeutic intervention in conditions such as schizophrenia, epilepsy, and neurodegenerative diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 18766-66-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,7,6 and 6 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 18766-66:
(7*1)+(6*8)+(5*7)+(4*6)+(3*6)+(2*6)+(1*6)=150
150 % 10 = 0
So 18766-66-0 is a valid CAS Registry Number.
InChI:InChI=1/C9H9NO5/c11-2-1-5-3-6(8(12)13)10-7(4-5)9(14)15/h1-3,7,10H,4H2,(H,12,13)(H,14,15)/b5-1-/t7-/m0/s1

18766-66-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name betalamic acid

1.2 Other means of identification

Product number -
Other names S-Betalamylsaeure

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:18766-66-0 SDS

18766-66-0Upstream product

18766-66-0Relevant articles and documents

Structural studies on the stereoisomerism of a natural dye miraxanthin I

Niziński, Stanis?aw,Popenda, ?ukasz,Rode, Micha? F.,Kumorkiewicz, Agnieszka,Fojud, Zbigniew,Paluch-Lubawa, Ewelina,Wybraniec, S?awomir,Burdziński, Gotard

, p. 18165 - 18174 (2019/12/02)

The chemical structure of a yellow dye present in Mirabilis jalapa L., miraxanthin I, was characterized by NMR spectroscopy. The extract of M. jalapa was analysed by a high-performance liquid chromatographic system (LC-DAD-FL-ESI-MS/MS) and the presence of miraxanthin I among other betaxanthins was confirmed. This dye was synthesized from previously generated methionine-betaxanthin by oxidation with 10% H2O2. The E/Z stereoisomers of miraxanthin I were found by NMR analysis to occur in a 50?:?33?:?10?:?7 ratio in aqueous solution (7E,9E?:?7Z,9E?:?7E,9Z?:?7Z,9Z configurations, respectively). Comparison of NMR data with chemical shifts obtained from quantum chemical calculations strongly suggests the presence of intramolecular hydrogen bonds which may favour a more rigid structure of the dye. This explains the highest fluorescence quantum yield among betaxanthins. The observed changes in the 1H NMR spectra during the measurements indicate on miraxanthin I hydrolysis for which a mechanism is proposed. The first step during the hydrolysis process is protonation of the nitrogen atom within the central bridge bond system which is observed in the ZE stereoisomer by NMR.

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