18766-66-0 Usage
Uses
Used in Pharmaceutical Industry:
(2S,4E)-1,2,3,4-Tetrahydro-4-(2-oxoethylidene)pyridine-2,6-dicarboxylic acid is used as a therapeutic agent for the treatment of neurological and psychiatric disorders. Its antagonistic action at the glycine site of the NMDA receptor helps regulate synaptic transmission and plasticity, making it a potential treatment for conditions such as schizophrenia, epilepsy, and neurodegenerative diseases.
Used in Neuroprotection:
(2S,4E)-1,2,3,4-Tetrahydro-4-(2-oxoethylidene)pyridine-2,6-dicarboxylic acid is used as a neuroprotective agent due to its antioxidant and immunomodulatory properties. It can help protect neurons from oxidative stress and inflammation, which are common in neurodegenerative diseases.
Used in Research:
(2S,4E)-1,2,3,4-Tetrahydro-4-(2-oxoethylidene)pyridine-2,6-dicarboxylic acid is used as a research tool to study the role of the NMDA receptor and its involvement in synaptic transmission, plasticity, and the pathophysiology of neurological and psychiatric disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 18766-66-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,7,6 and 6 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 18766-66:
(7*1)+(6*8)+(5*7)+(4*6)+(3*6)+(2*6)+(1*6)=150
150 % 10 = 0
So 18766-66-0 is a valid CAS Registry Number.
InChI:InChI=1/C9H9NO5/c11-2-1-5-3-6(8(12)13)10-7(4-5)9(14)15/h1-3,7,10H,4H2,(H,12,13)(H,14,15)/b5-1-/t7-/m0/s1
18766-66-0Relevant academic research and scientific papers
Structural studies on the stereoisomerism of a natural dye miraxanthin I
Niziński, Stanis?aw,Popenda, ?ukasz,Rode, Micha? F.,Kumorkiewicz, Agnieszka,Fojud, Zbigniew,Paluch-Lubawa, Ewelina,Wybraniec, S?awomir,Burdziński, Gotard
, p. 18165 - 18174 (2019/12/02)
The chemical structure of a yellow dye present in Mirabilis jalapa L., miraxanthin I, was characterized by NMR spectroscopy. The extract of M. jalapa was analysed by a high-performance liquid chromatographic system (LC-DAD-FL-ESI-MS/MS) and the presence of miraxanthin I among other betaxanthins was confirmed. This dye was synthesized from previously generated methionine-betaxanthin by oxidation with 10% H2O2. The E/Z stereoisomers of miraxanthin I were found by NMR analysis to occur in a 50?:?33?:?10?:?7 ratio in aqueous solution (7E,9E?:?7Z,9E?:?7E,9Z?:?7Z,9Z configurations, respectively). Comparison of NMR data with chemical shifts obtained from quantum chemical calculations strongly suggests the presence of intramolecular hydrogen bonds which may favour a more rigid structure of the dye. This explains the highest fluorescence quantum yield among betaxanthins. The observed changes in the 1H NMR spectra during the measurements indicate on miraxanthin I hydrolysis for which a mechanism is proposed. The first step during the hydrolysis process is protonation of the nitrogen atom within the central bridge bond system which is observed in the ZE stereoisomer by NMR.
