187671-41-6

Upstream product

• 84547-45-5 (RS)-1-phenylthiopentan-3-ol 
• 108643-99-8 1-(phenylthio)-3-pentanone 
• 27098-65-3 3-phenylsulfanyl-propionaldehyde 

Downstream Products

• 148153-94-0 (R)-1-(phenylsulfonyl)-3-pentanol 

Relevant academic research and scientific papers

Preparation of Sulfur-Containing Optically Active Secondary Alcohols Based on Pichia farinosa-Catalyzed anti-Prelog-Rule Reduction as the Key Step

A Pichia farinosa IAM 4682 mediated reduction of sulfur containing ketones afforded secondary alcohols with (R)-absolute configuration. For example, 4-(phenylthio)-2-butanone and 4-(phenylsulfonyl)-2-butanone afforded (R)-4-(phenylthio)-2-butanol (91%ee) in 90% yield and (R)-4-(phenylsulfonyl)-2-butanol (97%ee) in 94% yield, respectively. In the case that the ee of the product was not satisfactory, any contaminating (S)-enantiomer was selectively oxidized by Rhodococcus rhodochrous IFO 15564 to leave pure (R)-enantiomer. The substrate specificity of Pichia farinosa-mediated reduction and Rhodococcus rhodochrous-mediated oxidation was further examined.

Photo-Biocatalytic Cascades for the Synthesis of Volatile Sulfur Compounds and Chemical Building Blocks

Biocatalysis is a branch of catalysis that exploits enzymes to perform highly stereoselective chemical transformations under mild and sustainable conditions. This Synpact highlights how biocatalysis can be used in the synthesis of chiral 1,3-mercaptoalkan

Photo-biocatalytic One-Pot Cascades for the Enantioselective Synthesis of 1,3-Mercaptoalkanol Volatile Sulfur Compounds

The synthesis of enantiomerically pure 1,3-mercaptoalkanol volatile sulfur compounds through a one-pot photo-biocatalytic cascade reaction is described. Two new KRED biocatalysts with opposite enantioselectivity were discovered and proved to be efficient

Kinetic resolution of β- and γ-hydroxy sulfides by fungal lipase from Humicola lanuginosa

Racemic β- and γ-hydroxy sulfides were resolved by Humicola lanuginosa lipase catalyzed transesterification using vinyl acetate both as acyl donor and solvent. The effect of substituents and spacer length on rate of reaction and enantioselectivity is obse

Enantioselective ruthenium-mediated hydrogenation: Developments and applications

A general preparation of chiral ruthenium(II) catalysts and the homogeneous enantioselective hydrogenation of prochiral olefins and keto groups are presented. Some applications to the synthesis of biologically active compounds are reported.

Skewphos-Ru(II): An efficient catalyst for asymmetric hydrogenation of functionalized ketones

Asymmetric hydrogenation of prochiral keto groups with (S,S) AND (R,R)- SkewphosRuBr2 prepared in situ is described. Good enaniomeric excesses up to 95% were obtained.

Asymmetric hydrogenation of phenylthio ketones with chiral Ru(II) catalysts

Asymmetric hydrogenation of phenylthio ketones using chiral Ru(II) catalysts is reported. Complete conversions and enatiomeric excesses up to 98% were obtained.