18774-50-0

Usage

Molecular Structure

Contains an amino group and a thiophene ring

Usage

Commonly used as a building block in pharmaceutical and agrochemical synthesis
Studied for potential therapeutic applications, especially as an anticancer agent

Functional Groups

Amino group (-NH2)
Carboxylic acid group (-COOH)
Thiophene ring

Applications

Valuable intermediate for creating diverse chemical compounds with various biological activities
Investigated for potential use as a photoactive material for organic electronic devices

Upstream product

• 7311-95-7 ethyl 2-amino-1-benzothiophene-3-carboxylate 

Downstream Products

• 1209006-08-5 cyclohexyl 4-[4-({2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl}carbonyl)piperazin-1-yl]piperidine-1-carboxylate 
• 1209006-15-4 1-[3-({4-[1-(cyclohexylcarbonyl)piperidin-4-yl]piperazin-1-yl}carbonyl)-1-benzothiophen-2-yl]-3-ethylurea 
• 1209006-98-3 cyclohexyl 4-{4-[(2-amino-1-benzothiophen-3-yl)-carbonyl]piperazin-1-yl}piperidine-1-carboxylate 
• 1209006-91-6 (2-amino-1-benzothiophen-3-yl){4-[1-(cyclohexylcarbonyl)piperidin-4-yl]piperazin-1-yl}methanone 

Relevant academic research and scientific papers

Discovery of novel (4-piperidinyl)-piperazines as potent and orally active acetyl-CoA carboxylase 1/2 non-selective inhibitors: F-Boc and triF-Boc groups are acid-stable bioisosteres for the Boc group

Novel (4-piperidinyl)-piperazine derivatives were synthesized and evaluated as ACC1/2 non-selective inhibitors. Optimization of the substituents on the nitrogen of the piperidine ring led to the identification of the fluorine substituted tert-butoxycarbonyl group. Advanced analog, 1,1,1-trifluoro-2- methylpropan-2-yl 4-{4-[(2-amino-6-methyl-1-benzothiophen-3-yl)carbonyl] piperazin-1-yl}piperidine-1-carboxylate (12c) showed potent inhibitory activities in enzyme-assay and cell-based assays. Compound 12c also exhibited reduction of hepatic de novo fatty acid synthesis in rats after oral administration.

NEW ACETYL COENZYME A CARBOXYLASE (ACC) INHIBITORS AND USES IN TREATMENTS OF OBESITY AND DIABETES MELLITUS - 087

The present invention relates to Acetyl Coenzyme A Carboxylase (ACC) inhibitors according to formula (I), or an enantiomer thereof, or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, E, L, Z and n are as defined herein, to processes for preparing such compounds, to pharmaceutical compositions containing them, to the use of such inhibitors and to methods for th eir therapeutic use, particularly in the treatments of obesity and diabetes mellitus.

GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF

The invention relates to glycogen phosphorylase inhibitor compounds, pharmaceutical compositions of these compounds, methods of treatment using the pharmaceutical compositions to treat diabetes, conditions associated with diabetes, and/or tissue ischemia,