187838-07-9

Basic information

• Product Name: 1-Propanone, 2-fluoro-3-hydroxy-3-methoxy-2-methyl-1-phenyl- (9CI)
• Synonyms: 1-Propanone, 2-fluoro-3-hydroxy-3-methoxy-2-methyl-1-phenyl- (9CI)
• CAS NO: 187838-07-9
• Molecular Formula: C11H13FO3
• Molecular Weight: 212.2175232
• Product Categories: ACETYLHALIDE
• Mol File: 187838-07-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Propanone, 2-fluoro-3-hydroxy-3-methoxy-2-methyl-1-phenyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 2-fluoro-3-hydroxy-3-methoxy-2-methyl-1-phenyl- (9CI)(187838-07-9)
• EPA Substance Registry System: 1-Propanone, 2-fluoro-3-hydroxy-3-methoxy-2-methyl-1-phenyl- (9CI)(187838-07-9)

Safety Data

• Hazardous Substances Data: 187838-07-9(Hazardous Substances Data)

Upstream product

• 3516-69-6 3-hydroxy-2-methyl-1-phenyl-2-propen-1-one 
• 67-56-1 methanol 

Relevant articles and documents

An efficient method for α-monofluorination of carbonyl compounds with molecular fluorine: Use of α-hydroxymethylene substituent as directing and activating groups

Molecular fluorine efficiently reacts with α-hydroxymethylene carbonyl compounds to give α-fluoro-α-formyl compounds in a highly site-specific manner. The fluorinated compounds mostly isolated as their hemiacetals with methanol are readily deformylated just by treatment with weak bases affording α-monofluorinated carbonyl compounds. In this fluorination method, the hydroxymethylene group serves not only as a directing group but also as the activating group of carbonyl compounds for fluorination. By this method, a series of α-fluoro carbonyl compounds including esters was synthesized in high yields.