3516-69-6

Basic information

• Product Name: 3-hydroxy-2-methyl-1-phenyl-2-propen-1-one
• Synonyms: 3-hydroxy-2-methyl-1-phenyl-2-propen-1-one
• CAS NO: 3516-69-6
• Molecular Weight: 162.188
• Mol File: 3516-69-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-hydroxy-2-methyl-1-phenyl-2-propen-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-2-methyl-1-phenyl-2-propen-1-one(3516-69-6)
• EPA Substance Registry System: 3-hydroxy-2-methyl-1-phenyl-2-propen-1-one(3516-69-6)

Safety Data

• Hazardous Substances Data: 3516-69-6(Hazardous Substances Data)

Upstream product

• 93-55-0 1-phenyl-propan-1-one 
• 109-94-4 formic acid ethyl ester 

Downstream Products

• 21120-36-5 1-fluoroethyl phenyl ketone 
• 187838-02-4 2-Fluoro-2-methyl-3-oxo-3-phenyl-propionaldehyde 
• 187838-07-9 2-Fluoro-3-hydroxy-3-methoxy-2-methyl-1-phenyl-propan-1-one 
• 58550-13-3 C₉H₁₃NO 
• 55253-39-9 (R)-1-hydroxy-1-phenylpropan-2-one oxime 
• 492-41-1 (1R,2S)-norephedrine 
• 37577-07-4 Norpseudoephedrine 
• 147269-20-3 2-hydroxy-5-methyl-6-phenyl-nicotinic acid 
• 14088-57-4 2-diazo-1-phenyl-1-propanone 

Relevant articles and documents

Synthesis of substituted benzenes from α-methylene ketones

A new general method for the synthesis of substituted benzenes from cyclic ketones having active methylene groups via the corresponding hydroxymethylene ketones and enamino-ketones has been developed. Formylation of these ketones with ethyl formate followed by enamination with pyrrolidine produces enamino-ketones which on reaction with threefold excess of malononitrile in boiling benzene in the presence of ammonium acetate in acetic acid gives the substituted benzenes in good yield. The reaction has been extended to aliphatic and aromatic ketones having active methylene groups to give substituted benzenes and biphenyls, respectively.