187960-08-3 Usage
Uses
Used in Biochemical Research:
Genistein-D4 (4-Hydroxyphenyl-2,3,5,6-D4) is used as a research tool for studying the role of tyrosine kinases and protein kinases in cellular processes. Its application in this field is due to its ability to competitively inhibit ATP, which is essential for the activity of these enzymes.
Used in Cancer Research:
In cancer research, Genistein-D4 (4-Hydroxyphenyl-2,3,5,6-D4) is used as an inhibitor of tumor cell proliferation and inducer of tumor cell differentiation. Its application in this field is attributed to its ability to cause cell-cycle arrest and apoptosis in certain cancer cell lines, such as Jurkat T-leukemia cells.
Used in Pharmaceutical Development:
Genistein-D4 (4-Hydroxyphenyl-2,3,5,6-D4) is used as a potential therapeutic agent in the development of drugs targeting cancer and other diseases involving tyrosine kinases and protein kinases. Its application in this industry is due to its demonstrated inhibitory effects on these enzymes, which are often dysregulated in disease states.
Used in Drug Interaction Studies:
In the field of pharmacology, Genistein-D4 (4-Hydroxyphenyl-2,3,5,6-D4) is used to study the interactions between drugs and their targets, such as the inhibition of GABA on recombinant GABAA receptors. This application is valuable for understanding the mechanisms of drug action and potential side effects.
Used in Analytical Chemistry:
Genistein-D4 (4-Hydroxyphenyl-2,3,5,6-D4) is used as a reference compound in analytical chemistry, particularly in the development and validation of methods for the detection and quantification of genistein and its derivatives. Its application in this field is due to its distinct chemical properties, such as its UV absorption maximum in ethanol.
Used in Drug Delivery Systems:
In the development of drug delivery systems, Genistein-D4 (4-Hydroxyphenyl-2,3,5,6-D4) can be used as a model compound to study the encapsulation, release, and targeting of bioactive molecules. Its application in this industry is based on its solubility properties and its potential for incorporation into various drug delivery platforms.
Check Digit Verification of cas no
The CAS Registry Mumber 187960-08-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,7,9,6 and 0 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 187960-08:
(8*1)+(7*8)+(6*7)+(5*9)+(4*6)+(3*0)+(2*0)+(1*8)=183
183 % 10 = 3
So 187960-08-3 is a valid CAS Registry Number.
187960-08-3Relevant academic research and scientific papers
Soidinsalo, Otto,Waehaelae, Kristiina
, p. 973 - 978 (2006)
Efficient synthesis of polydeuterated di-O-sulfates of three isoflavones, daidzein (1), genistein (2), glycitein (3), is described. The isoflavones were first deuterated with CF3COOD under microwave irradiation to yield daidzein-d6 (
Synthesis of D4-Genistein, a Stable Deutero Labeled Isoflavone, by a Perdeuteration - Selective Dedeuteration Approach
Waehaelae, Kristiina,Rasku, Sirpa
, p. 7287 - 7290 (2007/10/03)
Isotopically labile D6-genistein 3, obtained by D3PO4/BF3 treatment of genistein 1, is dedeuterated to the stable D4-genistein 4 by methanolic HCl.
