187976-69-8

Upstream product

• 70853-26-8 N-carbobenzoxy-L-leucinal 
• 172487-18-2 ethyl Phenylphosphinate 

Downstream Products

• 187976-71-2 [(S)-2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-1-hydroxy-4-methyl-pentyl]-phenyl-phosphinic acid ethyl ester 
• 187976-70-1 ((S)-2-Amino-1-hydroxy-4-methyl-pentyl)-phenyl-phosphinic acid ethyl ester 

Relevant academic research and scientific papers

Novel peptidyl phosphorus derivatives as inhibitors of human calpain I

Dipeptidyl phosphorus compounds were synthesized as potential bioisosteric mimics of peptide α-ketoesters and α-ketoacids. α- Ketophosphonate Cbz-Leu-Leu-P(O)(OCH3)2 (1b), containing an α-ketoester bioisostere, inhibits human calpain

Phosphorous-containing cysteine and serine protease inhibitors

The present invention is directed to novel phosphorous-containing inhibitors of cysteine or serine proteases. Methods for the use of the protease inhibitors are also described.