Novel peptidyl phosphorus derivatives as inhibitors of human calpain I

Article abstract of DOI:10.1021/jm980325e

Dipeptidyl phosphorus compounds were synthesized as potential bioisosteric mimics of peptide α-ketoesters and α-ketoacids. α- Ketophosphonate Cbz-Leu-Leu-P(O)(OCH₃)₂ (1b), containing an α-ketoester bioisostere, inhibits human calpain